ArticleCurrent biology : CB2015
Phenotypic characterization of speed-associated gait changes in mice reveals modular organization of locomotor networks.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
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141 citing papers in PubMed.
- Cross-species identification of conserved and divergent locomotor kinematic strategies using AutoGaitA.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.Neural regeneration research · 2026Article
- Transcriptomic analysis of spinal V1 interneurons informs their multifunctional role in motor output.Nature communications · 2026Article
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice.iScience · 2026Article
- Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Probabilistic Perceptual Decisions during Navigation Are Driven by a Small Subpopulation of Neurons in a Single Cortical Column of the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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- Compensatory scaling of modulatory neural populations in response to motor challenges.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Inhibitory circuits control leg movements duringeLife · 2026Article
- An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.bioRxiv : the preprint server for biology · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- Specific recruitment properties of spinal reflex of thigh muscle in sprinter.Scientific reports · 2025Article
- Foot placement control underlies stable locomotion across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025Article
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- Neural substrates of cold nociception ineLife · 2025Article
81 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Studies of locomotion in mice suggest that circuits controlling the alternating between left and right limbs may have a modular organization with distinct locomotor circuits being recruited at different speeds. It is not clear, however, whether such a modular organization reflects specific behavioral outcomes expressed at different speeds of locomotion. Here, we use detailed kinematic analyses to search for signatures of a modular organization of locomotor circuits in intact and genetically modified mice moving at different speeds of locomotion. We show that wild-type mice display three distinct gaits: two alternating, walk and trot, and one synchronous, bound. Each gait is expressed in distinct ranges of speed with phenotypic inter-limb and intra-limb coordination. A fourth gait, gallop, closely resembled bound in most of the locomotor parameters but expressed diverse inter-limb coordination. Genetic ablation of commissural V0V neurons completely removed the expression of one alternating gait, trot, but left intact walk, gallop, and bound. Ablation of commissural V0V and V0D neurons led to a loss of walk, trot, and gallop, leaving bound as the default gait. Our study provides a benchmark for studies of the neuronal control of locomotion in the full range of speeds. It provides evidence that gait expression depends upon selection of different modules of neuronal ensembles.
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