Evidence map›Paper›PMID 25959854›Full record

ArticleHIV medicine2015

Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe.

M Mansfeld, A Skrahina, L Shepherd, A Schultze, A M Panteleev, R F Miller, J M Miro, I Zeltina, S Tetradov, H Furrer and 10 more

Registry-linked trialAbstract readComparative StudyMulticenter Study
In one paragraph

Article in HIV medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02699736 (EuroSIDA Prospective Observational Cohort Study on Clinical and Virological Outcome of European Patients Infected With HIV), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02699736 enrolling by invitationnot on this map

EuroSIDA Prospective Observational Cohort Study on Clinical and Virological Outcome of European Patients Infected With HIV

Typeobservational_patient_registrySponsorRigshospitalet, DenmarkRan1994 to 2030Enrolled23,000ConditionsHIV, Hepatitis B, Hepatitis C, AIDS
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. "East" in Europe-Health Dimension through the Lens of the UKInternational journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

M MansfeldCHIP (Centre for Health and Infectious Disease Research), Department of Infectious Diseases, Section 2100, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
A SkrahinaResearch Institute of Pulmonology and Pulmonary Tuberculosis, Minsk, Belarus.
L ShepherdDepartment of Infection and Population Health, University College London Medical School, London, UK.
A SchultzeDepartment of Infection and Population Health, University College London Medical School, London, UK.
A M PanteleevTB Hospital #2, St Petersburg, Russia.
R F MillerCentre for Sexual Health & HIV Research, Mortimer Market Centre, University College London, London, UK.
J M MiroInfectious Diseases Service, Hospital Clinic, University of Barcelona, Barcelona, Spain.
I ZeltinaInfectology Centre of Latvia, Riga, Latvia.
S Tetradov'Dr Victor Babes' Hospital of Tropical and Infectious Diseases, Bucharest, Romania.
H FurrerDepartment of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland.
O KirkCHIP (Centre for Health and Infectious Disease Research), Department of Infectious Diseases, Section 2100, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
A GrzeszczukDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
N BolokadzeInfectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia.
A MatteelliInstitute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.
F A PostKing's College Hospital NHS Foundation Trust, London, UK.
J D LundgrenCHIP (Centre for Health and Infectious Disease Research), Department of Infectious Diseases, Section 2100, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
A MocroftDepartment of Infection and Population Health, University College London Medical School, London, UK.
Amw EfsenCHIP (Centre for Health and Infectious Disease Research), Department of Infectious Diseases, Section 2100, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
D N PodlekarevaCHIP (Centre for Health and Infectious Disease Research), Department of Infectious Diseases, Section 2100, Rigshospitalet - University of Copenhagen, Copenhagen, Denmark.
TB:HIV study group in EuroCoord

Funding

Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
FIC NIH HHS D43 TW007124
6 · The paper itself

Abstract

objectivesThe aim of the study was to investigate the organization and delivery of HIV and tuberculosis (TB) health care and to analyse potential differences between treatment centres in Eastern (EE) and Western Europe (WE).

methodsThirty-eight European HIV and TB treatment centres participating in the TB:HIV study within EuroCoord completed a survey on health care management for coinfected patients in 2013 (EE: 17 respondents; WE:21; 76% of all TB:HIV centres). Descriptive statistics were obtained for regional comparisons. The reported data on health care strategies were compared with actual clinical practice at patient level via data derived from the TB:HIV study.

resultsRespondent centres in EE comprised: Belarus (n = 3), Estonia (1), Georgia (1), Latvia (1), Lithuania (1), Poland (4), Romania (1), the Russian Federation (4) and Ukraine (1); those in WE comprised: Belgium (1), Denmark (1), France (1), Italy (7), Spain (2), Switzerland (1) and UK (8). Compared with WE, treatment of HIV and TB in EE are less often located at the same site (47% in EE versus 100% in WE; P < 0.001) and less often provided by the same doctors (41% versus 90%, respectively; P = 0.002), whereas regular screening of HIV-infected patients for TB (80% versus 40%, respectively; P = 0.037) and directly observed treatment (88% versus 20%, respectively; P < 0.001) were more common in EE. The reported availability of rifabutin and second- and third-line anti-TB drugs was lower, and opioid substitution therapy (OST) was available at fewer centres in EE compared with WE (53% versus 100%, respectively; P < 0.001).

conclusionsMajor differences exist between EE and WE in relation to the organization and delivery of health care for HIV/TB-coinfected patients and the availability of anti-TB drugs and OST. Significant discrepancies between reported and actual clinical practices were found in EE.

Indexed as

Antitubercular AgentsCoinfectionCross-Sectional StudiesEuropeEurope, EasternHealth SurveysHIV InfectionsHumansOpiate Substitution TreatmentRifabutinTuberculosisAntitubercular AgentsRifabutindelivery of health careEuropeHIVintegratedtuberculosis

Identifiers

PMID25959854
PMCPMC5111860

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.