Evidence map›Paper›PMID 25959743›Full record

ArticleJournal of comparative effectiveness research2015

Value of a small control group for estimating intervention effectiveness: results from simulations of immunization effectiveness studies.

Sonja S Hutchins, Cedric Brown, Robert Mayberry, William Sollecito

Abstract read
In one paragraph

Article in Journal of comparative effectiveness research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sonja S HutchinsOffice of Minority Health & Health Equity, Centers for Disease Control & Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
Cedric BrownNational Center for Immunization & Respiratory Diseases, Centers for Disease Control & Prevention, GA, USA.
Robert MayberryDepartment of Community Health & Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
William SollecitoPublic Health Leadership Program, University of North Carolina Gillings School of Global Public Health, NC, USA.

Funding

Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI KLEMENT, BRENDA · 2012 to 2018
$24.8M
TCC for Health Disparties: Informing & Influencing Health Policy and PracticeU54MD008173 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI SATCHER, DAVID · 2012 to 2016
$13.4M
Women's Health Intervention StudyP20MD006881 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI AKINTOBI, TABIA HENRY · 2012 to 2016
$6.0M
NIMHD NIH HHS P20 MD006881NIMHD NIH HHS U54 MD007588NIMHD NIH HHS U54 MD008173
6 · The paper itself

Abstract

aimTo improve evidence for public health practice, the conduct of effectiveness studies by practitioners is needed and may be stimulated if knowledge that smaller than usual samples may provide the same reliability of intervention effect size as larger samples. MATERIALS &

methodsWe examined reliability of intervention effect using computerized simulations of 2000 hypothetical immunization effectiveness studies from an actual study population and by small (30 and 60) and larger (100 and 200) control groups compared with an intervention group of 200 participants. RESULTS &

conclusionAcross simulated studies, the mean intervention effect (14%) and effect sizes were equivalent regardless of control group size and equal to the actual study effect. These results are relevant for similarly designed and executed studies and indicate that studies with smaller control groups can generate valid and accurate evidence for effective public health practice in communities.

Indexed as

community intervention studyeffectiveness studyimmunization effectiveness studysmall control groupsmall sample size

Identifiers

PMID25959743
PMCPMC4905819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.