Evidence map›Paper›PMID 25959649›Full record

Observational studyMagnetic resonance imaging2015

Detection of hand and leg motor tract injury using novel diffusion tensor MRI tractography in children with central motor dysfunction.

Jeong-Won Jeong, Jessica Lee, David O Kamson, Harry T Chugani, Csaba Juhász

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Magnetic resonance imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jeong-Won JeongTranslational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA; Department of Neurology, School of Medicine, Wayne State University, Detroit, MI, USA. Electronic address: jeongwon@pet.wayne.edu.
Jessica LeeSchool of Medicine, Wayne State University, Detroit, MI, USA.
David O KamsonTranslational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, USA.
Harry T ChuganiTranslational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA; Department of Neurology, School of Medicine, Wayne State University, Detroit, MI, USA.
Csaba JuhászTranslational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA; Department of Neurology, School of Medicine, Wayne State University, Detroit, MI, USA.
Children's Hospital of Michigan · USWayne State University · US

Funding

Novel DWI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery.R01NS089659 · NINDS · WAYNE STATE UNIVERSITY · PI JEONG, JEONG-WON · 2015 to 2025
$3.7M
Novel MRI Approaches to Improve Presurgical Benefit-Risk Evaluation in Pediatric Epilepsy SurgeryR56NS089659 · NINDS · WAYNE STATE UNIVERSITY · PI Jeong-Won Jeong · 2026 to 2026
$551k
NINDS NIH HHS NS089659NINDS NIH HHS R01 NS089659NINDS NIH HHS R56 NS089659
6 · The paper itself

Abstract

purposeTo examine whether an objective segmenation of corticospinal tract (CST) associated with hand and leg movements can be used to detect central motor weakness in the corresponding extremities in a pediatric population. MATERIAL AND

methodsThis retrospective study included diffusion tensor imaging (DTI) of 25 children with central paresis affecting at least one limb (age: 9.0±4.2years, 15 boys, 5/13/7 children with left/right/both hemispheric lesions including ischemia, cyst, and gliosis), as well as 42 pediatric control subjects with no motor dysfunction (age: 9.0±5.5years, 21 boys, 31 healthy/11 non-lesional epilepsy children). Leg- and hand-related CST pathways were segmented using DTI-maximum a posteriori (DTI-MAP) classification. The resulting CST volumes were then divided by total supratentorial white matter volume, resulting in a marker called "normalized streamline volume ratio (NSVR)" to quantify the degree of axonal loss in separate CST pathways associated with leg and hand motor functions. A receiver operating characteristic curve was applied to measure the accuracy of this marker to identify extremities with motor weakness.

resultsNSVR values of hand/leg CST selectively achieved the following values of accuracy/sensitivity/specificity: 0.84/0.84/0.57, 0.82/0.81/0.55, 0.78/0.75/0.55, 0.79/0.81/0.54 at a cut-off of 0.03/0.03/0.03/0.02 for right hand CST, left hand CST, right leg CST, and left leg CST, respectively. Motor weakness of hand and leg was most likely present at the cut-off values of hand and leg NSVR (i.e., 0.029/0.028/0.025/0.020 for left-hand/right-hand/left-leg/right-leg). The control group showed a moderate age-related increase in absolute CST volumes and a biphasic age-related variation of the normalized CST volumes, which were lacking in the paretic children.

conclusionsThis study demonstrates that DTI-MAP classification may provide a new imaging tool to quantify axonal loss in children with central motor dysfunction. Using this technique, we found that early-life brain lesions affect the maturational trajectory of the primary motor pathway which may be used as an effective marker to facilitate evidence-based treatment of paretic children.

Indexed as

AdolescentChildChild, PreschoolDiffusion Tensor ImagingEfferent PathwaysFemaleHandHumansImage Interpretation, Computer-AssistedInfantLegMaleParesisPyramidal TractsReproducibility of ResultsSensitivity and SpecificityBrain maturationChildrenCorticospinal tractDiffusion tensor imagingHemiparesisVolume

Identifiers

PMID25959649
PMCPMC4466077
OpenAlexW1842323170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.