ArticleJournal of clinical periodontology2015
Increased infection with key periodontal pathogens during gestational diabetes mellitus.
Article in Journal of clinical periodontology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Functional Characterization of a Putative Sortase FA1364 inInternational journal of molecular sciences · 2026Article
- Gestational diabetes alters subgingival pathobiont composition.Acta odontologica Scandinavica · 2026Article
- Association Between Maternal C-Reactive Protein (CRP) Levels and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Connection between oral health and chronic diseases.MedComm · 2025Review
- The Association between Gestational Diabetes Mellitus and Infections in Pregnancy-Systematic Review and Meta-Analysis.Microorganisms · 2023Review
- Review
- Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens.Journal of applied oral science : revista FOB · 2023Article
- Tobacco smoke exacerbates Filifactor alocis pathogenicity.Journal of clinical periodontology · 2023Article
- Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?Journal of translational medicine · 2022Article
- Association of general health and lifestyle factors with the salivary microbiota - Lessons learned from the ADDITION-PRO cohort.Frontiers in cellular and infection microbiology · 2022Article
- The Microbiome in Periodontitis and Diabetes.Frontiers in oral health · 2022Review
- Multi-omics analysis reveals the host-microbe interactions in aged rhesus macaques.Frontiers in microbiology · 2022Article
- Maternal Periodontal Disease: A Possible Risk Factor for Adverse Pregnancy Outcomes in the Qassim Region of Saudi Arabia.Journal of pharmacy & bioallied sciences · 2021Article
- Article
- Porphyromonas gingivalis fimbrial protein Mfa5 contains a von Willebrand factor domain and an intramolecular isopeptide.Communications biology · 2021Article
- Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women.Geburtshilfe und Frauenheilkunde · 2020Article
- The salivary microbiota in health and disease.Journal of oral microbiology · 2020Review
- Quantitative analysis of key periodontopathic bacteria in gestational diabetic and non-diabetic women.Journal of diabetes and metabolic disorders · 2019Article
- Peptide-Based Inhibitors of Fimbrial Biogenesis in Porphyromonas gingivalis.Infection and immunity · 2019Article
- The oral microbiome and adverse pregnancy outcomes.International journal of women's health · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
aimGestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. MATERIALS AND
methodsFour case-control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA.
resultsGingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01).
conclusionsDiabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.