ArticleHuman brain mapping2015
Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease.Human brain mapping · 2018Trial
- Hippocampal sub-regional shape and physical activity in older adults.Hippocampus · 2016Trial
- Article
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Increasing disclosures of older adult maltreatment: a review of best practices for interviewing older adult eyewitnesses and victims.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2024Article
- Mapping mesoscale connectivity within the human hippocampus.NeuroImage · 2023Article
- A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics.Frontiers in neuroinformatics · 2023Article
- Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer's disease spectrum.Frontiers in aging neuroscience · 2023Article
- Subcortical shape in pediatric and adult obsessive-compulsive disorder.Depression and anxiety · 2022Article
- Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age.Frontiers in aging neuroscience · 2022Article
- A Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study.Schizophrenia bulletin · 2021Article
- Peer victimization and the association with hippocampal development and working memory in children with ADHD and typically-developing children.Scientific reports · 2021Article
- Proteomic and Transcriptomic Analyses Reveal Pathological Changes in the Entorhinal Cortex Region that Correlate Well with Dysregulation of Ion Transport in Patients with Alzheimer's Disease.Molecular neurobiology · 2021Article
- Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research.Neurology. Genetics · 2021Review
- Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.Molecular neurobiology · 2021Article
- The effect of body mass index on hippocampal morphology and memory performance in late childhood and adolescence.Hippocampus · 2021Article
- Sex-specific associations between subcortical morphometry in childhood and adult alcohol consumption: A 17-year follow-up study.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Newer approaches to characterizing hippocampal morphology can provide novel insights regarding cognitive function across the lifespan. We comprehensively assessed the relationships among age, hippocampal morphology, and hippocampal-dependent cognitive function in 137 healthy individuals across the adult lifespan (18-86 years of age). They underwent MRI, cognitive assessments and genotyping for Apolipoprotein E status. We measured hippocampal subfield volumes using a new multiatlas segmentation tool (MAGeT-Brain) and assessed vertex-wise (inward and outward displacements) and global surface-based descriptions of hippocampus morphology. We examined the effects of age on hippocampal morphology, as well as the relationship among age, hippocampal morphology, and episodic and working memory performance. Age and volume were modestly correlated across hippocampal subfields. Significant patterns of inward and outward displacement in hippocampal head and tail were associated with age. The first principal shape component of the left hippocampus, characterized by a lengthening of the antero-posterior axis was prominently associated with working memory performance across the adult lifespan. In contrast, no significant relationships were found among subfield volumes and cognitive performance. Our findings demonstrate that hippocampal shape plays a unique and important role in hippocampal-dependent cognitive aging across the adult lifespan, meriting consideration as a biomarker in strategies targeting the delay of cognitive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.