ArticleAmerican journal of medical genetics. Part C, Seminars in medical genetics2015
Developmental trajectories as autism phenotypes.
Article in American journal of medical genetics. Part C, Seminars in medical genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Pooled it
- Cognitive, Language, and Behavioral Outcomes in Children With Autism Spectrum Disorders Exposed to Early Comprehensive Treatment Models: A Meta-Analysis and Meta-Regression.Frontiers in psychiatry · 2021Pooled it
- Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes.Autism research : official journal of the International Society for Autism Research · 2026Article
- Fever-like temperatures improve cognitive deficits in the Scn2a autism mouse model via increases in potassium channel activity.Molecular psychiatry · 2026Article
- Advances in supporting development in autistic children and youth.BMJ (Clinical research ed.) · 2026Review
- Co-occurring Conditions and Education Services Among Transition-Age Adolescents With Autism.Pediatrics open science · 2026Article
- Developmental Trajectories of Adaptive Behavior from Toddlerhood to Middle Adulthood in Autism.Autism in adulthood · 2026Article
- Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.bioRxiv : the preprint server for biology · 2026Article
- Urban-Rural Differences and Sex-Specific Cognitive Effects on Autism Symptom Trajectories: A Longitudinal Study of Autistic Children in Taiwan.Autism research : official journal of the International Society for Autism Research · 2026Article
- Diversity of words and words for diversity.Frontiers in psychiatry · 2026Article
- Discrepancies between parent-reported and clinician-rated autism severity: roles of sex and age.Frontiers in psychiatry · 2026Article
- Effect of Alzheimer's disease medications on neurocognitive outcomes in children and adolescents with autism spectrum disorder and low IQ: a scoping review.Translational psychiatry · 2025Article
- Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity.Translational psychiatry · 2025Article
- Camouflaging Autism in Pursuit of Friendship and Intimate Relationships: A Systematic Review.Autism in adulthood · 2025Review
- The Association Between Autism Symptomatology and Adaptive Functioning Over Six Months: Findings from the Pilot Phase of the PARC Study.Journal of autism and developmental disorders · 2025Article
- Probability of Intervention Benefit in the Early Start Denver Model.Journal of autism and developmental disorders · 2025Article
- How Technology Advances Research and Practice in Autism Spectrum Disorder: A Narrative Review on Early Detection, Subtype Stratification, and Intervention.Brain sciences · 2025Review
- Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya.Journal of autism and developmental disorders · 2025Article
- Figure disembedding facility and reduced left visual field bias are linked to the social dimension of autistic traits.Attention, perception & psychophysics · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Numerous studies of Autism Spectrum Disorder have attempted to link behavioral phenotypes to genetic findings. Reliance on cross-sectional behavioral data in samples that span wide age ranges may have limited this endeavor because ASD behaviors are not static within individuals across development. This study uses quantitative methods to describe specific aspects of changes in autism-related and more general behaviors in order to yield trajectories that could be used in place of single time-point data as behavioral phenotypes in neurobiological studies of both Autism Spectrum Disorders and overlapping conditions. Building on previous analyses, we examined trajectories of parent-reported social-communication deficits, social adaptive functioning, and two types of repetitive behaviors, repetitive sensory motor (RSM) behaviors and insistence on sameness (IS) behaviors, in a relatively large sample of participants referred for possible autism at age 2 years and followed into young adulthood (n=85). A strength of this sample was the diverse range of outcomes, including young adults with intellectual disability and persistent autism related difficulties, those with IQs in the borderline or average range who continued to experience functional impairment related to Autism Spectrum Disorders, and a small group of young adults (n=8) with IQs in the average range who were judged to be functioning socially and adaptively at age-appropriate levels at age 19 years, despite a previous childhood diagnosis of autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.