ArticlePsycho-oncology2016
The longitudinal relationship between quality of life and survival in advanced stage cancer.
Article in Psycho-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Relationship between quality of life before treatment and survival in patients with hematological malignancies: A meta-analysis.Fukushima journal of medical science · 2025Pooled it
- Impact of quality of life on mortality risk in patients with esophageal cancer: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2024Pooled it
- Joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis.BMC medical research methodology · 2016Pooled it
- Acupuncture vs. Massage for Insomnia and Pain in Advanced Cancer: Exploratory RCT.Journal of pain and symptom management · 2026Trial
- Alkaline phosphatase decline and pain response as predictors of overall survival benefit in patients treated with radium-223: a post hoc analysis of the REASSURE study.British journal of cancer · 2025Trial
- A whole food, plant-based randomized controlled trial in metastatic breast cancer: feasibility, nutrient, and patient-reported outcomes.Breast cancer research and treatment · 2024Trial
- The Interplay of Quality of Life and Satisfaction with Nursing Care in Cancer Patients: A Narrative Review.Clinics and practice · 2026Review
- Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Measuring What Matters: RECIST Response Does Not Predict HRQoL in Early-Phase Clinical Trials.Cancers · 2026Article
- Insights into the Knowledge and Barriers of Oncofertility Among Oncology Nurses in Saudi Arabia.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Clinical study of separation surgery combined with intraoperative vertebroplasty andWorld journal of surgical oncology · 2025Article
- Quality of life and survival in patients with uterine carcinosarcoma: A tertiary center observational study.Gynecologic oncology reports · 2025Article
- Association between sensory processing sensitivity and quality of life among cancer patients: a mediation and moderation of resilience and social determinants.Health and quality of life outcomes · 2024Article
- Spinal Metastases of the Vertebrae: Three Main Categories of Pain.Life (Basel, Switzerland) · 2024Review
- A Whole Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Feasibility, Nutrient, and Patient-Reported Outcomes.Research square · 2023Article
- Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review.Journal of bone oncology · 2022Review
- Changes in Patient-Reported Health Status in Advanced Cancer Patients from a Symptom Management Clinic: A Longitudinal Study Conducted in China.Journal of oncology · 2022Article
- Physical Activity, Sitting Time, and Quality of Life among Breast and Gynaecology Cancer Survivors.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Quality of life for older patients with cancer: a review of the evidence supporting melatonin use.Aging clinical and experimental research · 2020Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesQuality of Life (QoL) at baseline is frequently found to be a prognostic factor in cancer studies. However, little is known about the relationship of the trajectory of QoL and survival in patients with advanced cancer. This study evaluates the effects of both level and change of QoL on survival to explore the potential of utilizing longitudinal information of QoL for prognosis.
methodsA series of joint models were used in a sample (N = 512) of patients diagnosed with advanced cancer (sample consisted of nine different cancer sites) with assessments of QoL across six time points and with survival information recorded up to 28 months after diagnosis. We used FACT-G as the QoL measure, and we evaluated the effects of change in QoL controlling for the time-dependent effects of chemotherapy and radiation.
resultsThe median survival for patients was 14.2 months, and 10% of the sample had survived beyond 28 months after the diagnosis of advanced cancer. The effect of change of QoL on survival was significant (hazard ratio = 0.98; p < 0.001) controlling for time-dependent treatment effects. Also, the slope of the trajectory in QoL was found to be a significant predictor of survival (hazard ratio = 0.18; p < 0.001).
conclusionThese preliminary findings suggest that the patient's longitudinal experience in QoL may be a significant prognostic factor of survival, a novel finding with potentially important implications in medical decision making. Longitudinal information on QoL can be used for updating the patient's prognosis of survival.
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