ArticleDevelopmental biology2015
MED GATA factors promote robust development of the C. elegans endoderm.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- A GATA factor radiation inbioRxiv : the preprint server for biology · 2025Article
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- Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematodeAmerican journal of physiology. Cell physiology · 2023Review
- Evolutionary Change in Gut Specification inJournal of developmental biology · 2023Review
- The long isoform of themicroPublication biology · 2023Article
- The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network.Development (Cambridge, England) · 2022Article
- Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development.Development (Cambridge, England) · 2022Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Evolutionary Dynamics of the SKN-1 → MED → END-1,3 Regulatory Gene Cascade inG3 (Bethesda, Md.) · 2020Article
- Evolution and Developmental System Drift in the Endoderm Gene Regulatory Network ofFrontiers in cell and developmental biology · 2020Review
- Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network.eLife · 2019Article
- RNA interference may result in unexpected phenotypes in Caenorhabditis elegans.Nucleic acids research · 2019Article
- A Strategy To Isolate Modifiers ofG3 (Bethesda, Md.) · 2018Article
- Quantitating transcription factor redundancy: The relative roles of the ELT-2 and ELT-7 GATA factors in the C. elegans endoderm.Developmental biology · 2018Article
- Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.PLoS biology · 2017Article
- Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo.Development (Cambridge, England) · 2017Article
- A transcriptional blueprint for a spiral-cleaving embryo.BMC genomics · 2016Article
- Article
- Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The MED-1,2 GATA factors contribute to specification of E, the progenitor of the Caenorhabditis elegans endoderm, through the genes end-1 and end-3, and in parallel with the maternal factors SKN-1, POP-1 and PAL-1. END-1,3 activate elt-2 and elt-7 to initiate a program of intestinal development, which is maintained by positive autoregulation. Here, we advance the understanding of MED-1,2 in E specification. We find that expression of end-1 and end-3 is greatly reduced in med-1,2(-) embryos. We generated strains in which MED sites have been mutated in end-1 and end-3. Without MED input, gut specification relies primarily on POP-1 and PAL-1. 25% of embryos fail to make intestine, while those that do display abnormal numbers of gut cells due to a delayed and stochastic acquisition of intestine fate. Surviving adults exhibit phenotypes consistent with a primary defect in the intestine. Our results establish that MED-1,2 provide robustness to endoderm specification through end-1 and end-3, and reveal that gut differentiation may be more directly linked to specification than previously appreciated. The results argue against an "all-or-none" description of cell specification, and suggest that activation of tissue-specific master regulators, even when expression of these is maintained by positive autoregulation, does not guarantee proper function of differentiated cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.