ReviewJournal of the American Medical Directors Association2015
Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research.
Review in Journal of the American Medical Directors Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05589870 (A Retrospective, Comparative Study, for the Assessment of a Novel System, an Algorithm for Medication Safety and Consultation for Chronic Polypharmacy Patients), which is not on this map. Cited by 274 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Retrospective, Comparative Study, for the Assessment of a Novel System, an Algorithm for Medication Safety and Consultation for Chronic Polypharmacy Patients
Who cites it
274 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effects of aquatic exercise on improving body composition and muscle strength in the older adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Reporting and representation of underserved groups in intervention studies for patients with multiple long-term conditions: a systematic review.Journal of the Royal Society of Medicine · 2024Pooled it
- Age-based exclusion is common and multifactorial in spinal RCTs: a systematic review and quantitative analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Pooled it
- A Systematic Review and Multilevel Regression Analysis Reveals the Comorbidity Prevalence in Cancer.Cancer research · 2023Pooled it
- Interventions for the empowerment of older people and informal caregivers in transitional care decision-making: short report of a systematic review.BMC geriatrics · 2023Pooled it
- Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- The effectiveness of different patient referral systems to shorten waiting times for elective surgeries: systematic review.BMC health services research · 2021Pooled it
- Pooled it
- PACE-It: An Integrated Multidisciplinary Technology-Assisted Approach to Person-Centered Care for Individuals with Complex Care Needs.Journal of general internal medicine · 2026Trial
- Impact of an 8-Year Intensive Lifestyle Intervention on an Index of Multimorbidity.Journal of the American Geriatrics Society · 2020Trial
- Phenotypic age metrics for risk stratification of chronic disease burden and all-cause mortality in adults.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Minimally Invasive Implant Rehabilitation in Geriatric Patients: A Comprehensive Narrative Review of Contemporary Strategies to Avoid Extensive Bone Augmentation Procedures.Geriatrics (Basel, Switzerland) · 2026Review
- Factors associated with sustained robustness in older adults: an 8-year multinational longitudinal study using SHARE data.BMC geriatrics · 2026Observational
- Sicker at all ages? Two decades of changing disease histories and mortality in the United States.International journal of epidemiology · 2026Article
- Exploring the Relationship Between Religion, Health, and Sociodemographic Factors in Brazil During the COVID-19 Pandemic.Journal of religion and health · 2026Article
- Health Literacy and Chronic Disease Self-Efficacy Among Older Adults with Multimorbidity: Evidence from Low-Resource Context.Healthcare (Basel, Switzerland) · 2026Article
- Associating Multimorbidity Patterns With Healthcare Utilization and Unmet Healthcare Needs Among Older Koreans Living Alone.Geriatrics & gerontology international · 2026Article
- Clinical care patterns in the 10-years prior to primary total hip replacement: a matched population-based case-control analysis in England.BMC medicine · 2026Article
- Exploring the association between common genetic deletions and aging: insights from the Canadian Longitudinal Study on Aging.GeroScience · 2026Article
- Role of Senescence in the Pathophysiology of Preeclampsia and Future Health.Hypertension (Dallas, Tex. : 1979) · 2026Review
214 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.