ArticleCellular immunology2015
Evolution of two prototypic T cell lineages.
Article in Cellular immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- An invariant VLR-like receptor refines the T-like cell framework in lamprey.Nature communications · 2026Article
- Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells.Nature communications · 2025Article
- Domain-Shuffling in the Evolution of Cyclostomes and Gnathostomes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE.Cell reports · 2023Article
- Spatial Metabolomics Reveals the Multifaceted Nature of Lamprey Buccal Gland and Its Diverse Mechanisms for Blood-Feeding.Communications biology · 2023Article
- TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family.International journal of molecular sciences · 2023Review
- Investigation of the Molecular Evolution of Treg Suppression Mechanisms Indicates a Convergent Origin.Current issues in molecular biology · 2023Article
- Interleukin-17 is disease promoting in early stages and protective in late stages of experimental periodontitis.PloS one · 2022Article
- Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages.Cells · 2021Review
- Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis.Nature immunology · 2021Article
- Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks.Immunogenetics · 2021Review
- Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis.Current opinion in immunology · 2020Review
- AncientJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.Journal of molecular biology · 2018Article
- Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.Nature genetics · 2018Article
- Characterization of Lamprey BAFF-like Gene: Evolutionary Implications.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Coevolution of T-cell receptors with MHC and non-MHC ligands.Immunological reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Jawless vertebrates, which occupy a unique position in chordate phylogeny, employ leucine-rich repeat (LRR)-based variable lymphocyte receptors (VLR) for antigen recognition. During the assembly of the VLR genes (VLRA, VLRB and VLRC), donor LRR-encoding sequences are copied in a step-wise manner into the incomplete germ-line genes. The assembled VLR genes are differentially expressed by discrete lymphocyte lineages: VLRA- and VLRC-producing cells are T-cell like, whereas VLRB-producing cells are B-cell like. VLRA(+) and VLRC(+) lymphocytes resemble the two principal T-cell lineages of jawed vertebrates that express the αβ or γδ T-cell receptors (TCR). Reminiscent of the interspersed nature of the TCRα/TCRδ locus in jawed vertebrates, the close proximity of the VLRA and VLRC loci facilitates sharing of donor LRR sequences during VLRA and VLRC assembly. Here we discuss the insight these findings provide into vertebrate T- and B-cell evolution, and the alternative types of anticipatory receptors they use for adaptive immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.