ArticleDental materials : official publication of the Academy of Dental Materials2015
Molecular weight and galloylation affect grape seed extract constituents' ability to cross-link dentin collagen in clinically relevant time.
Article in Dental materials : official publication of the Academy of Dental Materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Polyphenol-functionalized silver nanoparticles promote differential remineralization and reinforcement of demineralized dentin.Journal of applied oral science : revista FOB · 2026Article
- Article
- Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.Clinical oral investigations · 2024Article
- Preliminary Evaluation of Bioactive Collagen-Polyphenol Surface Nanolayers on Titanium Implants: An X-ray Photoelectron Spectroscopy and Bone Implant Study.Journal of functional biomaterials · 2024Article
- Theaflavin -3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen.Frontiers in bioengineering and biotechnology · 2024Article
- Does the pH of the grape seed extract interfere in the biomodification capacity of dentin collagen?Brazilian dental journal · 2024Article
- Dual-functional etchants that simultaneously demineralize and stabilize dentin render collagen resistant to degradation for resin bonding.Dental materials : official publication of the Academy of Dental Materials · 2023Article
- Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability.Materials (Basel, Switzerland) · 2022Article
- Distinct effects of polyphenols and solvents on dentin collagen crosslinking interactions and biostability.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Theaflavins as a novel cross-linker quickly stabilize demineralized dentin collagen against degradation.Scientific reports · 2021Article
- Dual-Functionality Evaluation of a Novel Collagen Crosslinking Resin.Journal of dental research · 2021Article
- Article
- Polyphenols in Dental Applications.Bioengineering (Basel, Switzerland) · 2020Review
- Effect of tea root-derived proanthocyanidin fractions on protection of dentin collagen.The Journal of international medical research · 2020Article
- Dimeric Proanthocyanidins on the Stability of Dentin and Adhesive Biointerfaces.Journal of dental research · 2020Article
- Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer.International journal of biomaterials · 2019Review
- Polyphenol uses in biomaterials engineering.Biomaterials · 2018Review
- Effects of epicatechin, a crosslinking agent, on human dental pulp cells cultured in collagen scaffolds.Journal of applied oral science : revista FOBArticle
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo investigate the relationship between the structures of polyphenolic compounds found in grape seed extract (GSE) and their activity in cross-linking dentin collagen in clinically relevant settings.
methodsRepresentative monomeric and dimeric GSE constituents including (+)-catechin (pCT), (-)-catechin (CT), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG), procyanidin B2 and a pCT-pCT dimer were purchased or synthesized. GSE was separated into low (PALM) and high molecular weight (PAHM) fractions. Human molars were processed into dentin films and beams. After demineralization, 11 groups of films (n=5) were treated for 1min with the aforementioned reagents (1wt% in 50/50 ethanol/water) and 1 group remained untreated. The films were studied by Fourier transform infrared spectroscopy (FTIR) followed by a quantitative mass spectroscopy-based digestion assay. Tensile properties of demineralized dentin beams were evaluated (n=7) after treatments (2h and 24h) with selective GSE species that were found to protect dentin collagen from collagenase.
resultsEfficacy of GSE constituents in cross-linking dentin collagen was dependent on molecular size and galloylation. Non-galloylated species with degree of polymerization up to two, including pCT, CT, EC, EGC, procyanidin B2 and pCT-pCT dimer were not active. Galloylated species were active starting from monomeric form, including ECG, EGCG, PALM, GSE and PAHM. PALM induced the best overall improvement in tensile properties of dentin collagen. SIGNIFICANCE: Identification under clinically relevant settings of structural features that contribute to GSE constituents' efficacy in stabilizing demineralized dentin matrix has immediate impact on optimizing GSE's use in dentin bonding.
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