ArticleDevelopmental biology2015
FGF signaling supports Drosophila fertility by regulating development of ovarian muscle tissues.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
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- Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis.PLoS genetics · 2023Article
- Distinct gene expression dynamics in germ line and somatic tissue during ovariole morphogenesis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2022Article
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- Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A single-cell atlas of the developingGenes & development · 2020Article
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- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
- Lmx1a is required for the development of the ovarian stem cell niche inDevelopment (Cambridge, England) · 2018Article
- Dissection and Staining of Drosophila Pupal Ovaries.Journal of visualized experiments : JoVE · 2018Article
- Myotube migration to cover and shape the testis ofBiology open · 2017Article
- Resolving in vivo gene expression during collective cell migration using an integrated RNAscope, immunohistochemistry and tissue clearing method.Mechanisms of development · 2017Article
- Influence of ovarian muscle contraction and oocyte growth on egg chamber elongation in Drosophila.Development (Cambridge, England) · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The thisbe (ths) gene encodes a Drosophila fibroblast growth factor (FGF), and mutant females are viable but sterile suggesting a link between FGF signaling and fertility. Ovaries exhibit abnormal morphology including lack of epithelial sheaths and muscle tissues that surround ovarioles. Here we investigated how FGF influences Drosophila ovary morphogenesis and identified several roles. Heartless (Htl) FGF receptor was found to be expressed within somatic cells at the larval and pupal stages, and phenotypes were uncovered using RNAi. Differentiation of terminal filament cells was affected, but this effect did not alter the ovariole number. In addition, proliferation of epithelial sheath progenitors, the apical cells, was decreased in both htl and ths mutants, while ectopic expression of the Ths ligand led to these cells' over-proliferation suggesting that FGF signaling supports ovarian muscle sheath formation by controlling apical cell number in the developing gonad. Additionally, live imaging of adult ovaries was used to show that htl RNAi mutants, hypomorphic mutants in which epithelial sheaths are present, exhibit abnormal muscle contractions. Collectively, our results demonstrate that proper formation of ovarian muscle tissues is regulated by FGF signaling in the larval and pupal stages through control of apical cell proliferation and is required to support fertility.
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