ArticleSurgery2015
Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue.
Article in Surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism.Archives of endocrinology and metabolism · 2018Guideline
- Trial
- Research status and frontier trends of near-infrared autofluorescence for parathyroid identification and protection: a bibliometric analysis from 2006 to 2026.Gland surgery · 2026Article
- Rapid Arbitrary-Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Robot-Assisted Resection of a Superior Prevascular Mediastinal Ectopic Parathyroid Adenoma by Subxiphoid Approach: A Case Report.Surgical case reports · 2026Article
- Recent advances of photoresponsive nanomaterials for diagnosis and treatment of acute kidney injury.Journal of nanobiotechnology · 2024Review
- Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore.Chemical & biomedical imaging · 2024Article
- Preoperative localisation of parathyroid adenomas using ultrasound-guided methylene blue dye injection.Polish journal of radiology · 2024Article
- Fluorescent Probes for Imaging in Humans: Where Are We Now?ACS nano · 2023Review
- Risk Factors for Calcium-Phosphate Disorders after Thyroid Surgery.Biomedicines · 2023Article
- Preclinical evaluation of molecularly targeted fluorescent probes in perfused amputated human limbs.Journal of biomedical optics · 2023Article
- Fluorescence-guided surgery: comprehensive review.BJS open · 2023Review
- Controlling Molecular Dye Encapsulation in the Hydrophobic Core of Core-Shell Nanoparticles for In Vivo Imaging.Biomedical materials & devices (New York, N.Y.) · 2023Review
- Single Camera-Based Dual-Channel Near-Infrared Fluorescence Imaging system.Sensors (Basel, Switzerland) · 2022Article
- Near-infrared fluorescent imaging techniques for the detection and preservation of parathyroid glands during endocrine surgery.Innovative surgical sciences · 2022Article
- Rapidly liver-clearable rare-earth core-shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window.Journal of nanobiotechnology · 2021Article
- Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection.Biomedical optics express · 2021Article
- Primary study of identification of parathyroid gland based on laser-induced breakdown spectroscopy.Biomedical optics express · 2021Article
- Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure.Biomedical optics express · 2020Article
- [Possibilities and perspectives of hyperspectral imaging in visceral surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Article
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7 authors.
Funding
Abstract
backgroundIdentification of diseased and normal parathyroid glands during parathyroid surgery can be challenging. The aim of this study was to assess whether near-infrared (NIR) fluorescence imaging using administration of a low-dose Methylene Blue (MB) at the start of the operation could provide optical guidance during parathyroid surgery and assist in the detection of parathyroid adenomas.
methodsPatients diagnosed with primary hyperparathyroidism planned for parathyroidectomy were included. Patients received 0.5 mg/kg MB intravenously directly after start of anesthesia. During the operation, NIR fluorescence imaging was performed to identify parathyroid adenomas. Imaging results were compared with a previous published feasibility study in which 12 patients received MB after intraoperative identification of the adenoma.
resultsA total of 13 patients were included in the current study. In 10 of 12 patients with a histologically proven adenoma, the adenoma was fluorescent. Mean signal to background ratio was 3.1 ± 2.8. Mean diameter of the resected lesions was 17 ± 9 mm (range 5-28 mm). Adenomas could be identified up to 145 minutes after administration, which was the longest timespan until resection. Interestingly, in 3 patients, a total of 6 normal parathyroid glands (median diameter 2.5 mm) with a signal to background ratio of 1.8 ± 0.4 were identified using NIR fluorescence imaging.
conclusionEarly administration of low-dose MB provided guidance during parathyroidectomy by identifying both parathyroid adenomas and normal parathyroid glands. In patients in whom difficult identification of the parathyroid adenoma is expected or when normal glands have to be identified, the administration of MB may improve surgical outcome.
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