Evidence map›Paper›PMID 25957898›Full record

ArticleCell stem cell2015

What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.

Valeria V Orlova, Christine L Mummery

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Frontiers in cardiovascular medicine · 2024
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valeria V OrlovaDepartment of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Electronic address: c.l.mummery@lumc.nl.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent issue of Cell, Theodoris et al. (2015) used a complex systems biology approach to model vascular aortic calcification caused by mutations in the NOTCH1 gene. Comparison of endothelial cells from patient hiPSCs and genetically matched controls under fluid flow revealed novel mechanisms underlying the disease.

Indexed as

Epigenesis, GeneticGene Regulatory NetworksFemaleHumansMaleReceptor, Notch1Receptor, Notch1

Identifiers

PMID25957898
OpenAlexW1531897430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.