ArticleReproductive biology and endocrinology : RB&E2015
The periovulatory endocrine milieu affects the uterine redox environment in beef cows.
Article in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Melatonin Enhances Embryo Quality in Japanese Black Cows During the Hot Season.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Progesterone increases metabolism via the pentose phosphate pathway in bovine uterine epithelial cells.Molecular biology reports · 2024Article
- The Effect of By-Pass Linseed Oil Supplementation on the Maternal Antioxidant System during the Embryo-Maternal Recognition Period in Ewes.Animals : an open access journal from MDPI · 2023Article
- Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle.Physiological genomics · 2022Article
- Endometrial receptivity in cattle: the mutual reprogramming paradigm.Animal reproduction · 2022Review
- Steroidal Regulation of Oviductal microRNAs Is Associated with microRNA-Processing in Beef Cows.International journal of molecular sciences · 2021Article
- The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction.Mediators of inflammation · 2019Article
- Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.PloS one · 2019Article
- Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle.Journal of animal science and biotechnology · 2018Article
- Maternal metabolism affects endometrial expression of oxidative stress and FOXL2 genes in cattle.PloS one · 2017Article
- Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity.Journal of animal science and biotechnology · 2017Article
- Pre-hatching embryo-dependent and -independent programming of endometrial function in cattle.PloS one · 2017Article
- Size of the Ovulatory Follicle Dictates Spatial Differences in the Oviductal Transcriptome in Cattle.PloS one · 2015Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn cattle, recent studies have shown positive associations between pre-ovulatory concentrations of estradiol (E2), progesterone (P4) at early diestrus and fertility. However, information on cellular and molecular mechanisms through which sex steroids regulate uterine function to support early pregnancy is lacking. Based on endometrial transcriptome data, objective was to compare function of the redox system in the bovine uterus in response to different periovulatory endocrine milieus.
methodsWe employed an animal model to control growth of the pre-ovulatory follicle and subsequent corpus luteum (CL). The large follicle-large CL group (LF-LCL, N=42) presented greater levels of E2 on the day of GnRH treatment (D0; 2.94 vs. 1.27 pg/mL; P=0.0007) and P4 at slaughter on D7 (3.71 vs. 2.62 ng/mL, P=0.01), compared with the small follicle-small CL group (SF-SCL, N=41). Endometrium and uterine washings (N=9, per group) were collected for analyses of variables associated with the uterine redox system.
resultsThe SF-SCL group had lower endometrial catalase (0.5 vs. 0.79 U/mg protein, P<0.001) and glutathione peroxidase (GPx; 2.0 vs. 2.43 nmol β-nicotinamide adenine dinucleotide phosphate reduced/min/mg protein, P=0.04) activity, as well as higher lipid peroxidation (28.5 vs. 17.43 nmol malondialdehyde/mg of protein, P<0.001) and superoxide dismutase (SOD) activity (44.77 vs. 37.76 U; P=0.04). There were no differences in the endometrial reactive species (RS) or glutathione (GSH) concentrations between the groups. The uterine washing samples showed no differences in the concentrations of RS or GSH or in total SOD activity (P>0.1). Additionally, catalase, GPx4, SOD1 and SOD2 gene expression was lower in the SF-SCL group than in the LF-LCL group.
conclusionsWe concluded that the intrauterine environment of cows from the LF-LCL group exhibited higher antioxidant activity than that of the cows from the SF-SCL group. We speculate that uterine receptivity and fertility are associated with an optimal redox environment, such as that present in the animals in the LF-LCL group.
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