Evidence map›Paper›PMID 25957793›Full record

Trial reportMalaria journal2015

The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.

Upeksha P Chandrasiri, Freya J I Fowkes, Jack S Richards, Christine Langer, Yue-Mei Fan, Steve M Taylor, James G Beeson, Kathryn G Dewey, Kenneth Maleta, Per Ashorn and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239693 (A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01239693 phase3active not recruitingnot on this map

A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)

TypeinterventionalSponsorTampere UniversityRan2011 to 2027Enrolled1,391ConditionsInfant Malnutrition, Malnutrition in PregnancyArmsIFA, MMN, LNS
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Upeksha P ChandrasiriDepartment of Medicine, Clinical Sciences Building, The University of Melbourne, Royal Parade, Parkville, VIC, 3052, Australia. upekshapc@gmail.com.
Freya J I FowkesMacfarlane Burnet Institute of Medical Research, 85 Commercial Road, Melbourne, Australia. fowkes@burnet.edu.au.
Jack S RichardsDepartment of Medicine, Clinical Sciences Building, The University of Melbourne, Royal Parade, Parkville, VIC, 3052, Australia. richards@burnet.edu.au.
Christine LangerMacfarlane Burnet Institute of Medical Research, 85 Commercial Road, Melbourne, Australia. langer@burnet.edu.au.
Yue-Mei FanDepartment for International Health, University of Tampere School of Medicine, Tampere, Finland. Yuemei.Fan@uta.fi.
Steve M TaylorDuke University Medical Center, Durham, North Carolina, USA. stevemyertaylor@gmail.com.
James G BeesonDepartment of Medicine, Clinical Sciences Building, The University of Melbourne, Royal Parade, Parkville, VIC, 3052, Australia. beeson@burnet.edu.au.
Kathryn G DeweyDepartment of Nutrition, University of California Davis, Davis, California, USA. kgdewey@ucdavis.edu.
Kenneth MaletaCollege of Medicine, University of Malawi, Blantyre, Malawi. ken.maleta@gmail.com.
Per AshornDepartment for International Health, University of Tampere School of Medicine, Tampere, Finland. per.ashorn@uta.fi.
Stephen J RogersonDepartment of Medicine, Clinical Sciences Building, The University of Melbourne, Royal Parade, Parkville, VIC, 3052, Australia. sroger@unimelb.edu.au.
Burnet Institute · AUUniversity of Melbourne · AUTampere University · FIDuke Medical Center · USUniversity of California, Davis · USUniversity of Malawi · MW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria and undernutrition frequently coexist, especially in pregnant women and young children. Nutrient supplementation of these vulnerable groups might reduce their susceptibility to malaria by improving immunity.

methodsAntibody immunity to antigens expressed by a placental-binding parasite isolate, a non-placental binding parasite isolate, merozoites and schizonts at enrolment (before 20 gestation weeks) and at 36 gestation weeks were measured in 1,009 Malawian pregnant women receiving a daily lipid-based nutrient supplement, multiple micronutrients or iron and folic acid, who were participants in a randomized clinical trial assessing the effects of nutrient supplementation on pregnancy outcomes and child development (registration ID: NCT01239693).

resultsAntibodies to placental-binding isolates significantly increased while antibodies to most merozoite antigens declined over pregnancy. Overall, after adjustment for covariates, the type of supplementation did not influence antibody levels at 36 gestation weeks or the rate of change in antibody levels from enrolment to 36 weeks. A negative association between maternal body mass index and opsonizing antibodies to placental-binding antigens (coefficient (95% CI) -1.04 (-1.84, -0.24), was observed. Similarly, women with higher socioeconomic status had significantly lower IgG and opsonizing antibodies to placental-binding antigens. Neither of these associations was significantly influenced by the supplementation type.

conclusionsIn the current cohort nutrient supplementation did not affect anti-malarial antibody responses, but poor and undernourished mothers should be a priority group in future trials.

Indexed as

Adaptive ImmunityAdolescentAdultAntibodies, ProtozoanCohort StudiesDietary SupplementsFemaleFolic AcidHumansIronLipid MetabolismMalariaMalawiMerozoitesMicronutrientsPlasmodiumAntibodies, ProtozoanFolic AcidIronMicronutrients

Identifiers

PMID25957793
PMCPMC4438573
OpenAlexW1510214365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.