ArticleJournal of neurology2015
Cognitive impairment and memory disorders in relapsing-remitting multiple sclerosis: the role of white matter, gray matter and hippocampus.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- The Prevalence of Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies.PloS one · 2024Pooled it
- Pooled it
- Retinal layers prognosticate cognitive progression independent of relapse activity in multiple sclerosis.Journal of neurology · 2026Article
- Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.Neuropsychology · 2026Article
- Validation of the Patient-Determined Disease Steps in ambulatory older adults with multiple sclerosis.Multiple sclerosis and related disorders · 2025Article
- Isolated cognitive impairment in people with multiple sclerosis: frequency, MRI patterns and its development over time.Journal of neurology · 2024Article
- Cognitive phenotypes in multiple sclerosis: mapping the spectrum of impairment.Journal of neurology · 2024Article
- Prevalence of cognitive impairment (CI) in patients with multiple sclerosis (MS): A systematic review and meta-analysis.Caspian journal of internal medicine · 2024Review
- Multiple sclerosis lesions that impair memory map to a connected memory circuit.Journal of neurology · 2023Article
- Multiple exposures to sevoflurane across postnatal development may cause cognitive deficits in older age.Pediatric research · 2023Article
- Mindfulness-based cognitive therapy combined with repetitive transracial magnetic stimulation (rTMS) on information processing and working memory of patients with multiple sclerosis.Caspian journal of internal medicine · 2022Article
- Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination.Nature communications · 2021Article
- The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis.Human brain mapping · 2021Article
- Immunomodulation Eliminates Inflammation in the Hippocampus in Experimental Autoimmune Encephalomyelitis, but Does Not Ameliorate Anxiety-Like Behavior.Frontiers in immunology · 2021Article
- Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus.Anesthesiology · 2019Article
- Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis.Hippocampus · 2018Article
- Multiple sclerosis and cognition: synaptic failure and network dysfunction.Nature reviews. Neuroscience · 2018Review
- Cognitive performance in multiple sclerosis: the contribution of intellectual enrichment and brain MRI measures.Journal of neurology · 2018Article
- The Contribution of Various MRI Parameters to Clinical and Cognitive Disability in Multiple Sclerosis.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive disorders occur in up to 65 % of multiple sclerosis (MS) patients; they have been correlated with different MRI measures of brain tissue damage, whole and regional brain atrophy. The hippocampal involvement has been poorly investigated in cognitively impaired (CI) MS patients. The objective of this study is to analyze and compare brain tissue abnormalities, including hippocampal atrophy, in relapsing-remitting MS (RRMS) patients with and without cognitive deficits, and to investigate their role in determining cognitive impairment in MS. Forty-six RRMS patients [20 CI and 26 cognitively preserved (CP)] and 25 age, sex and education-matched healthy controls (HCs) underwent neuropsychological evaluation and 3-Tesla anatomical MRI. T2 lesion load (T2-LL) was computed with a semiautomatic method, gray matter volume and white matter volume were estimated using SIENAX. Hippocampal volume (HV) was obtained by manual segmentation. Brain tissues volumes were compared among groups and correlated with cognitive performances. Compared to HCs, RRMS patients had significant atrophy of WM, GM, left and right Hippocampus (p < 0.001). Compared to CP, CI RRMS patients showed higher T2-LL (p = 0.02) and WM atrophy (p = 0.01). In the whole RRMS group, several cognitive tests correlated with brain tissue abnormalities (T2-LL, WM and GM atrophy); only verbal memory performances correlated with left hippocampal atrophy. Our results emphasize the role of T2-LL and WM atrophy in determining clinically evident cognitive impairment in MS patients and provide evidence that GM and hippocampal atrophy occur in MS patients regardless of cognitive status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.