ReviewJournal of neurology2015
Review of delirium in patients with Parkinson's disease.
Review in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2024Guideline
- Association between postoperative delirium and mortality in elderly patients undergoing hip fractures surgery: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Video-based Detection of Delirium in Hospitalized Adults.medRxiv : the preprint server for health sciences · 2026Article
- Video-based detection of Delirium in hospitalized adults.PLOS digital health · 2026Article
- Novel predictors of postoperative delirium after awake subthalamic nucleus deep brain stimulation for Parkinson's disease.BMJ neurology open · 2026Article
- Discontinuation or acute unplanned cessation of oral dopaminergic medications in persons with Parkinson's disease: A practice review.Journal of Parkinson's disease · 2025Review
- Improving recognition and management of inpatient delirium in Parkinson's disease: evidence review and implications for clinical care.Frontiers in aging neuroscience · 2025Review
- Cognitive disorders in advanced Parkinson's disease: challenges in the diagnosis of delirium.Neurological research and practice · 2024Review
- Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies.Age and ageing · 2024Article
- Causal relationships between delirium and Parkinson's disease: a bidirectional two-sample Mendelian randomization study.European journal of medical research · 2024Article
- Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Documentation and diagnosis of delirium in Parkinson's disease.Acta psychiatrica Scandinavica · 2023Article
- Using Machine Learning Algorithms to Predict High-Risk Factors for Postoperative Delirium in Elderly Patients.Clinical interventions in aging · 2023Article
- Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease under General Anesthesia.Parkinson's disease · 2022Article
- Parkinson's disease and Covid-19: Is there an impact of ethnicity and the need for palliative care.International review of neurobiology · 2022Article
- Treatment paradigms in Parkinson's Disease and Covid-19.International review of neurobiology · 2022Article
- Urinary Tract Infection in Parkinson's Disease.Journal of Parkinson's disease · 2022Review
- Spotlight on non-motor symptoms and Covid-19.International review of neurobiology · 2022Article
- First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes.NPJ Parkinson's disease · 2021Article
- A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations.Schizophrenia bulletin · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is common and has a number of associated neuropsychiatric disturbances. Of these, delirium has historically been under-recognised. Delirium is an acute disturbance of attention and awareness that fluctuates, and is accompanied by an additional disturbance of cognition. As delirium is known to carry a particularly poor prognosis in terms of morbidity and mortality, and the relationship between delirium and dementia is becoming better defined, we completed a literature review of delirium in the context of PD. A literature search was completed using the databases PubMed, Embase and Ovid Medline. PubMed (1945-2014) was searched in September 2014; Embase (1974-2014); and Ovid Medline (1946-2014) in October 2014. The search terms 'delirium' and 'Parkinsons' in combination were used. Large studies using a robust definition of delirium were lacking in PD. There is the suggestion that PD is a risk factor for delirium and that delirium negatively impacts upon the motor symptom trajectory. Deficits in the neurotransmitters dopamine and acetylcholine are implicated in the pathophysiology of delirium in PD. Systemic inflammation also appears to have a role. Treatment of delirium in PD should include medication review and cautious use of atypical antipsychotics where pharmacological treatment is indicated. Of the atypical antipsychotics studied, quetiapine has the least extrapyramidal side effects. Evidence suggests a specific link between delirium and PD but well-designed clinical studies to evaluate the prevalence, impact and treatment of delirium in PD are required. Given the potential to improve outcomes through delirium prevention we conclude that delirium in PD is an area worthy of further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.