ReviewDNA repair2015
Chromatin plasticity in response to DNA damage: The shape of things to come.
Review in DNA repair, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Nuclear functions regulated by the VRK1 kinase.Nucleus (Austin, Tex.) · 2024Review
- VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells.International journal of molecular sciences · 2024Article
- Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.International journal of molecular sciences · 2021Article
- An insight into understanding the coupling between homologous recombination mediated DNA repair and chromatin remodeling mechanisms in plant genome: an update.Cell cycle (Georgetown, Tex.) · 2021Review
- Regulation of Nuclear Mechanics and the Impact on DNA Damage.International journal of molecular sciences · 2021Review
- Nucleosome remodeling at origins of global genome-nucleotide excision repair occurs at the boundaries of higher-order chromatin structure.Genome research · 2019Article
- Radioresistant Sf9 insect cells readily undergo an intrinsic mode of apoptosis in response to histone deacetylase (HDAC) inhibition.Molecular and cellular biochemistry · 2018Article
- Chromatin and nucleosome dynamics in DNA damage and repair.Genes & development · 2017Review
- Chromosome territory relocation paradigm during DNA damage response: Some insights from molecular biology to physics.Nucleus (Austin, Tex.) · 2017Article
- Super-Resolution Localization Microscopy of γ-H2AX and Heterochromatin after Folate Deficiency.International journal of molecular sciences · 2017Article
- Regulation of DNA Repair Mechanisms: How the Chromatin Environment Regulates the DNA Damage Response.International journal of molecular sciences · 2017Review
- Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair.International journal of molecular sciences · 2017Review
- Histone chaperone networks shaping chromatin function.Nature reviews. Molecular cell biology · 2017Review
- Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage.Molecular cell · 2016Article
- Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin.Genome research · 2016Article
- Epigenome Maintenance in Response to DNA Damage.Molecular cell · 2016Review
- Linking replication stress with heterochromatin formation.Chromosoma · 2016Review
- Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage.DNA repair · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
DNA damage poses a major threat to cell function and viability by compromising both genome and epigenome integrity. The DNA damage response indeed operates in the context of chromatin and relies on dynamic changes in chromatin organization. Here, we review the molecular bases of chromatin alterations in response to DNA damage, focusing on core histone mobilization in mammalian cells. Building on our current view of nucleosome dynamics in response to DNA damage, we highlight open challenges and avenues for future development. In particular, we discuss the different levels of regulation of chromatin plasticity during the DNA damage response and their potential impact on cell function and epigenome maintenance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.