ArticleSchizophrenia research2015
Neurobiology of insight deficits in schizophrenia: An fMRI study.
Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Schizophrenia bulletin · 2022Pooled it
- Neural correlates of altered insight in frontotemporal dementia: a systematic review.NeuroImage. Clinical · 2019Pooled it
- The Effects of Add-on Fronto-Temporal Transcranial Direct Current Stimulation (tDCS) on Auditory Verbal Hallucinations, Other Psychopathological Symptoms, and Insight in Schizophrenia: A Randomized, Double-Blind, Sham-Controlled Trial.The international journal of neuropsychopharmacology · 2018Trial
- Conscious vision: investigating visual hallucination awareness in Lewy body disease.Brain communications · 2026Article
- Psychometric evaluation of the Arabic language version of the Birchwood Insight Scale in patients with schizophrenia.BMC psychiatry · 2024Article
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Article
- Where the public health principles meet the individual: a framework for the ethics of compulsory outpatient treatment in psychiatry.BMC medical ethics · 2022Article
- Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [Neuropsychiatric disease and treatment · 2021Article
- Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis.Neuropsychiatric disease and treatment · 2021Article
- [Research on brain network for schizophrenia classification based on resting-state functional magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia.Schizophrenia research · 2019Article
- Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies.Neuropsychiatric disease and treatment · 2019Article
- Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders.Schizophrenia research · 2018Article
- Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study.NeuroImage. Clinical · 2018Article
- Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia.World journal of psychiatry · 2016Article
- Is it me? Verbal self-monitoring neural network and clinical insight in schizophrenia.Psychiatry research · 2015Article
- Recent Neurobiological Insights into the Concept of Insight in Psychosis.Indian journal of psychological medicineArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Prior research has shown insight deficits in schizophrenia to be associated with specific neuroimaging changes (primarily structural) especially in the prefrontal sub-regions. However, little is known about the functional correlates of impaired insight. Seventeen patients with schizophrenia (mean age 40.0±10.3; M/F=14/3) underwent fMRI on a Philips 3.0 T Achieva system while performing on a self-awareness task containing self- vs. other-directed sentence stimuli. SPM5 was used to process the imaging data. Preprocessing consisted of realignment, coregistration, and normalization, and smoothing. A regression analysis was used to examine the relationship between brain activation in response to self-directed versus other-directed sentence stimuli and average scores on behavioral measures of awareness of symptoms and attribution of symptoms to the illness from Scale to Assess Unawareness of Mental Disorders. Family Wise Error correction was employed in the fMRI analysis. Average scores on awareness of symptoms (1=aware; 5=unaware) were associated with activation of multiple brain regions, including prefrontal, parietal and limbic areas as well as basal ganglia. However, average scores on correct attribution of symptoms (1=attribute; 5=misattribute) were associated with relatively more localized activation of prefrontal cortex and basal ganglia. These findings suggest that unawareness and misattribution of symptoms may have different neurobiological basis in schizophrenia. While symptom unawareness may be a function of a more complex brain network, symptom misattribution may be mediated by specific brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.