Evidence map›Paper›PMID 25957412›Full record

ReviewThe Journal of biological chemistry2015

Writing and Reading the Tubulin Code.

Ian Yu, Christopher P Garnham, Antonina Roll-Mecak

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 185 citations in OpenAlex.

  1. PKD2-like proteins targetProceedings of the National Academy of Sciences of the United States of America · 2026
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  2. Review
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  6. GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells.International journal of molecular sciences · 2024
    Article
  7. Article
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  10. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
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  13. Review
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  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ian YuFrom the Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, NINDS, and.
Christopher P GarnhamFrom the Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, NINDS, and.
Antonina Roll-MecakFrom the Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, NINDS, and NHLBI, National Institutes of Health, Bethesda, Maryland 20892 Antonina@mail.nih.gov.
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

Mechanisms of molecular machines that regulate the neuronal cytoskeletonZIANS003122 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROLL-MECAK, ANTONINA · 2010 to 2016
$9.9M
Intramural NIH HHS ZIA NS003122PHS HHS 1ZIANS003122-05
6 · The paper itself

Abstract

Microtubules give rise to intracellular structures with diverse morphologies and dynamics that are crucial for cell division, motility, and differentiation. They are decorated with abundant and chemically diverse posttranslational modifications that modulate their stability and interactions with cellular regulators. These modifications are important for the biogenesis and maintenance of complex microtubule arrays such as those found in spindles, cilia, neuronal processes, and platelets. Here we discuss the nature and subcellular distribution of these posttranslational marks whose patterns have been proposed to constitute a tubulin code that is interpreted by cellular effectors. We review the enzymes responsible for writing the tubulin code, explore their functional consequences, and identify outstanding challenges in deciphering the tubulin code.

Indexed as

AnimalsHumansKineticsMicrotubulesModels, BiologicalModels, MolecularMultienzyme ComplexesPeptide SynthasesProtein MultimerizationProtein Processing, Post-TranslationalTubulinMultienzyme ComplexesPeptide SynthasesTubulintubulin polyglutamylasecytoskeletonmicrotubulemicrotubule-associated protein (MAP)microtubule dynamicsmicrotubule motorpost-translational modification (PTM)TTLLtubulintubulin post-translational modificationstubulin tyrosine ligase

Identifiers

PMID25957412
PMCPMC4498056
OpenAlexW1680718768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.