Evidence map›Paper›PMID 25957410›Full record

ReviewThe Journal of biological chemistry2015

Building the Microtubule Cytoskeleton Piece by Piece.

Ray Alfaro-Aco, Sabine Petry

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The large cytoplasmic volume of oocyte.The Journal of reproduction and development · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Synergistic effects ofmicroPublication biology · 2021
    Article
  15. Exposing a novel genetic interaction betweenmicroPublication biology · 2020
    Article
  16. Article
  17. The Vacuolating Autotransporter Toxin (Vat) ofFrontiers in cellular and infection microbiology · 2020
    Article
  18. Article
  19. Harnessing the power of microbial nanowires.Microbial biotechnology · 2018
    Review
  20. Integrin and microtubule crosstalk in the regulation of cellular processes.Cellular and molecular life sciences : CMLS · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ray Alfaro-AcoFrom the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544.
Sabine PetryFrom the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 spetry@princeton.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Building the Chromosome Segregation Machinery from ScratchDP2GM123493 · NIGMS · PRINCETON UNIVERSITY · PI PETRY, SABINE · 2016 to 2016
$2.4M
Role and Mechanism of Microtubule Nucleation within the Mitotic SpindleR00GM100013 · NIGMS · PRINCETON UNIVERSITY · PI PETRY, SABINE · 2013 to 2015
$745k
NIGMS NIH HHS 4R00GM100013NIGMS NIH HHS DP2 GM123493NIGMS NIH HHS R00 GM100013NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

The microtubule (MT) cytoskeleton gives cells their shape, organizes the cellular interior, and segregates chromosomes. These functions rely on the precise arrangement of MTs, which is achieved by the coordinated action of MT-associated proteins (MAPs). We highlight the first and most important examples of how different MAP activities are combined in vitro to create an ensemble function that exceeds the simple addition of their individual activities, and how the Xenopus laevis egg extract system has been utilized as a powerful intermediate between cellular and purified systems to uncover the design principles of self-organized MT networks in the cell.

Indexed as

AnimalsCytoskeletonFemaleHumansMicrotubule-Associated ProteinsMicrotubulesModels, BiologicalMolecular Motor ProteinsSpindle ApparatusXenopus laevisMicrotubule-Associated ProteinsMolecular Motor Proteinscell divisioncytoskeletonmicrotubulemicrotubule-associated protein (MAP)mitotic spindle

Identifiers

PMID25957410
PMCPMC4498055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.