Evidence map›Paper›PMID 25957404›Full record

ReviewThe Journal of biological chemistry2015

Actin Mechanics and Fragmentation.

Enrique M De La Cruz, Margaret L Gardel

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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  8. Metareview: a survey of active matter reviews.The European physical journal. E, Soft matter · 2025
    Review
  9. GALNT9 enrichment attenuates MPPBiology direct · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Twist response of actin filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Enrique M De La CruzFrom the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 and enrique.delacruz@yale.edu.
Margaret L Gardelthe Institute for Biophysical Dynamics, James Franck Institute, and Department of Physics, University of Chicago, Chicago, Illinois 60637 gardel@uchicago.edu.

Funding

Actin filament elasticity and actin-binding protein functionR01GM097348 · NIGMS · YALE UNIVERSITY · PI DE LA CRUZ, ENRIQUE M · 2011 to 2018
$3.1M
NIGMS NIH HHS GM097348NIGMS NIH HHS R01 GM097348
6 · The paper itself

Abstract

Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of such force-activated chemistries and dynamic steady states reflects an important challenge for future work that will provide valuable insights as to how the actin cytoskeleton engenders mechanoresponsiveness of living cells.

Indexed as

Actin CytoskeletonActinsAnimalsBiomechanical PhenomenaHumansModels, MolecularProtein Structure, TertiaryActinsactinbiophysicscell motilitycofilincytoskeletonpersistence lengthrheologyseveringstrainstress

Identifiers

PMID25957404
PMCPMC4498053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.