ArticleThe Journal of antimicrobial chemotherapy2015
Within-host diversity of MRSA antimicrobial resistances.
Article in The Journal of antimicrobial chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Mobile genetic element-driven genomic changes in a community-associated methicillin-resistantMicrobial genomics · 2024Article
- Genomic Insights of a Methicillin-Resistant Biofilm-ProducingBioMed research international · 2024Article
- Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Abundant resistome determinants in rhizosphere soil of the wild plant Abutilon fruticosum.AMB Express · 2023Article
- Conditions Necessary for the Transfer of Antimicrobial Resistance in Poultry Litter.Antibiotics (Basel, Switzerland) · 2023Article
- Quantifying patient- and hospital-level antimicrobial resistance dynamics inmedRxiv : the preprint server for health sciences · 2023Article
- Functional annotation of rhizospheric phageome of the wild plant speciesFrontiers in microbiology · 2023Article
- Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution.PLoS computational biology · 2022Article
- Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage.mSystems · 2022Article
- Comparative Genomics of Three Novel Jumbo Bacteriophages Infecting Staphylococcus aureus.Journal of virology · 2021Article
- The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?Pharmaceuticals (Basel, Switzerland) · 2021Review
- Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia.JAC-antimicrobial resistance · 2020Article
- Using genomics to understand inter- and intra- outbreak diversity ofMicrobial genomics · 2020Article
- Staphylococci: Evolving Genomes.Microbiology spectrum · 2019Review
- Bacteriophages benefit from generalized transduction.PLoS pathogens · 2019Article
- Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data.PLoS computational biology · 2019Article
- Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.Genome biology · 2018Article
- Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens.Frontiers in microbiology · 2018Review
- Emerging multidrug resistance in community-associated Staphylococcus aureus involved in skin and soft tissue infections and nasal colonization.The Journal of antimicrobial chemotherapy · 2017Article
- Next-Generation Sequence Analysis Reveals Transfer of Methicillin Resistance to a Methicillin-Susceptible Staphylococcus aureus Strain That Subsequently Caused a Methicillin-Resistant Staphylococcus aureus Outbreak: a Descriptive Study.Journal of clinical microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesMRSA is a major antimicrobial resistance (AMR) pathogen. The reservoir of infecting isolates is colonization, which is the site of evolutionary selection. The aim was to identify if AMRs in colonizing MRSA populations diversified and potential mechanisms of resistance gene transfer in vivo.
methodsNasal swabs from 38 MRSA carriers admitted to hospital were plated and 20 individual colonies from each patient tested for phenotypic antibiotic susceptibility and genetically for lineage, carriage of four prophages and three plasmid families. Free bacteriophages were detected in swabs as well as their capacity for transducing resistance genes.
resultsNine (24%) patients carried phenotypic AMR variants and 24 (63%) carried prophage and plasmid variants. If a single colony was selected for testing, the probability of detecting all AMR in that patient was 87%. Sixty-four different AMR and mobile genetic element (MGE) profiles were detected, mostly in the MRSA CC22 background (where CC stands for clonal complex), with up to 8 profiles per patient. Nearly half of the patients carried detectable free bacteriophages and phages successfully transduced resistance genes between laboratory and patient isolates in vitro. WGS showed MRSA core genomes were stable, while AMR and MGEs varied.
conclusions'Clouds' of MRSA variants that have acquired or lost AMR and MGEs are common in nasal colonizing populations and bacteriophages may play an important role in gene transfer. Accurate estimation of AMR and genetic variability has implications for diagnostics, epidemiology, antimicrobial stewardship and understanding the evolutionary selection of AMR in colonizing populations.
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