ReviewCold Spring Harbor perspectives in medicine2015
Confrontation, Consolidation, and Recognition: The Oocyte's Perspective on the Incoming Sperm.
Review in Cold Spring Harbor perspectives in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Small RNAs: an ideal choice as sperm quality biomarkers.Frontiers in reproductive health · 2024Article
- Deciphering the complexity of sperm transcriptome reveals genes governing functional membrane and acrosome integrities potentially influence fertility.Cell and tissue research · 2021Article
- RNA element discovery from germ cell to blastocyst.Nucleic acids research · 2019Article
- Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell linesToxicology research · 2018Article
- Gamete-mediated mate choice: towards a more inclusive view of sexual selection.Proceedings. Biological sciences · 2018Review
- Sperm morphology and the evolution of intracellular sperm-egg interactions.Ecology and evolution · 2018Article
- Mechanisms that prevent catastrophic interactions between paternal chromosomes and the oocyte meiotic spindle.Cell cycle (Georgetown, Tex.) · 2018Review
- Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa.RNA biology · 2017Article
- Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications.Nature reviews. Genetics · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From the oocyte's perspective, the incoming sperm poses a significant challenge. Despite (usually) arising from a male of the same species, the sperm is a "foreign" body that may carry with it additional, undesirable factors such as transposable elements (mainly retroposons) into the egg. These factors can arise either during spermatogenesis or while the sperm is moving through the epididymis or the female genital tract. Furthermore, in addition to the paternal genome, the sperm also carries its own complex repertoire of RNAs into the egg that includes mRNAs, lncRNAs, and sncRNAs. Last, the paternal genome itself is efficiently packaged into a protamine (nucleo-toroid) and histone (nucleosome)-based chromatin scaffold within which much of the RNA is embedded. Taken together, the sperm delivers a far more complex package to the egg than was originally thought. Understanding this complexity, at both the compositional and structural level, depends largely on investigating sperm chromatin from both the genomic (DNA packaging) and epigenomic (RNA carriage and extant histone modifications) perspectives. Why this complexity has arisen and its likely purpose requires us to look more closely at what happens in the oocyte when the sperm gains entry and the processes that then take place preparing the paternal (and maternal) genomes for syngamy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.