ArticleCarcinogenesis2015
Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas.
Article in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
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- Distinctive molecular features of radiation-induced thyroid cancers.Science advances · 2025Article
- Single-Cell Sequencing: An Emerging Tool for Biomarker Development in Nuclear Emergencies and Radiation Oncology.Cancers · 2025Review
- Pathogenesis of cancers derived from thyroid follicular cells.Nature reviews. Cancer · 2023Review
- Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure toScientific reports · 2022Article
- Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.Science (New York, N.Y.) · 2021Article
- Adverse outcome pathways, key events, and radiation risk assessment.International journal of radiation biology · 2021Review
- Utility of gene expression studies in relation to radiation exposure and clinical outcomes: thyroid cancer in the Ukrainian-American cohort and late health effects in a MAYAK worker cohort.International journal of radiation biology · 2021Review
- Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment.International journal of radiation biology · 2021Article
- Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.Radiation oncology (London, England) · 2020Article
- Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure.PloS one · 2020Article
- Doses of Ukrainian female clean-up workers with diagnosed breast cancer.Radiation and environmental biophysics · 2018Article
- Radiation and Thyroid Cancer.International journal of molecular sciences · 2017Review
- Article
- Integration of a radiation biomarker into modeling of thyroid carcinogenesis and post-Chernobyl risk assessment.Carcinogenesis · 2016Article
- Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort.Carcinogenesis · 2015Article
- Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design.Drug design, development and therapyArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previous study on papillary thyroid carcinomas (PTC) in young patients who were exposed to (131)iodine from the Chernobyl fallout revealed an exclusive gain of chromosomal band 7q11.23 in exposed cases compared to an age-matched control cohort. CLIP2, a gene located within band 7q11.23 was shown to be differentially expressed between exposed and non-exposed cases at messenger RNA and protein level. Therefore, a standardized procedure for CLIP2 typing of PTCs has been developed in a follow-up study. Here we used CLIP2 typing data on 117 post-Chernobyl PTCs from two cohorts of exposed patients with individual dose estimates and 24 non-exposed controls to investigate a possible quantitative dose-response relationship of the CLIP2 marker. The 'Genrisk-T' cohort consisted of 45 PTCs and the 'UkrAm' cohort of 72 PTCs. Both cohorts differed in mean dose (0.59 Gy Genrisk-T, 1.2 Gy UkrAm) and mean age at exposure (AaE) (2 years Genrisk-T, 8 years UkrAm), whilst the median latency (16 years Genrisk-T, 18 years UkrAm) was comparable. We analyzed the association between the binary CLIP2 typing and continuous thyroid dose with logistic regression. A clear positive dose-response relationship was found for young PTC cases [age at operation (AaO) < 20 years, AaE < 5 years]. In the elder age group a higher proportion of sporadic tumors is assumed due to a negligible dose response, suggesting different molecular mechanisms in sporadic and radiation-induced cases. This is further supported by the association of elder patients (AaO > 20 years) with positivity for BRAF V600E mutation.
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