ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult life.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- CD36 in asthma: from a candidate immunometabolic checkpoint to genetic susceptibility.Frontiers in immunology · 2026Review
- B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM.The Journal of experimental medicine · 2023Article
- B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.Frontiers in toxicology · 2023Review
- Article
- Glycan Reactive Natural Antibodies and Viral Immunity.Viral immunology · 2020Review
- Article
- B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade.Cell reports · 2018Article
- A Hard(y) Look at B-1 Cell Development and Function.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- The immunology of the allergy epidemic and the hygiene hypothesis.Nature immunology · 2017Review
- PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Defining Natural Antibodies.Frontiers in immunology · 2017Article
- Editorial: Natural Antibodies in Health and Disease.Frontiers in immunology · 2017Article
- Immunological Outcomes of Antibody Binding to Glycans Shared between Microorganisms and Mammals.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Pulmonary α-1,3-Glucan-Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Manipulation of the glycan-specific natural antibody repertoire for immunotherapy.Immunological reviews · 2016Review
- B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production.Frontiers in immunology · 2016Review
- Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus.Frontiers in immunology · 2016Article
- TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Currently, ∼20% of the global population suffers from an allergic disorder. Allergies and asthma occur at higher rates in developed and industrialized countries. It is clear that many human atopic diseases are initiated neonatally and herald more severe IgE-mediated disorders, including allergic asthma, which is driven by the priming of Th2 effector T cells. The hygiene hypothesis attempts to link the increased excessively sanitary conditions early in life to a default Th2 response and increasing allergic phenomena. Despite the substantial involvement of IgE Abs in such conditions, little attention has been paid to the effects of early microbial exposure on the B cell repertoire prior to the initiation of these diseases. In this study, we use Ab-binding assays to demonstrate that Streptococcus pneumoniae and house dust mite (HDM) bear similar phosphorylcholine (PC) epitopes. Neonatal C57BL/6 mice immunized with a PC-bearing pneumococcal vaccine expressed increased frequencies of PC-specific B cells in the lungs following sensitizing exposure to HDM as adults. Anti-PC IgM Abs in the lung decreased the interaction of HDM with pulmonary APCs and were affiliated with lowered allergy-associated cell infiltration into the lung, IgE production, development of airway hyperresponsiveness, and Th2 T cell priming. Thus, exposure of neonatal mice to PC-bearing pneumococci significantly reduced the development of HDM-induced allergic disease during adult life. Our findings demonstrate that B cells generated against conserved epitopes expressed by bacteria, encountered early in life, are also protective against the development of allergic disease during adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.