ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Downregulation of THRB drives immune microenvironment suppression and poor outcomes, acting as a dual biomarker for clear cell renal cell carcinoma.BMC cancer · 2026Article
- Editorial: Follicular helper T cells in immunity and autoimmunity, volume II.Frontiers in immunology · 2026Article
- B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond.International journal of molecular sciences · 2024Review
- Transcriptional programming of CD4Science immunology · 2023Article
- The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5Immunity · 2022Article
- Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease.Frontiers in immunology · 2022Review
- Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination.Immunological reviews · 2022Review
- BCOR gene alterations in hematologic diseases.Blood · 2021Review
- Functional differentiation and regulation of follicular T helper cells in inflammation and autoimmunity.Immunology · 2021Review
- Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment.Cellular & molecular immunology · 2021Review
- BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.The Journal of experimental medicine · 2019Article
- Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.Nature communications · 2018Article
- Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- BCL6 represses antiviral resistance in follicular T helper cells.Journal of leukocyte biology · 2017Article
- Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection.Cell reports · 2016Article
- Regulation of hematopoietic development by ZBTB transcription factors.International journal of hematology · 2016Review
- Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.Nature immunology · 2016Article
- CXCL13 is a plasma biomarker of germinal center activity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
T follicular helper (Tfh) cells are essential for germinal centers (GCs) and most long-term humoral immunity. Differentiation of Tfh cells depends on the transcriptional repressor B cell CLL/lymphoma 6 (Bcl6). Bcl6 mediates gene repression via the recruitment of corepressors. Currently, it is unknown how Bcl6 recruits corepressors to regulate gene expression of Tfh cells. In this article, we demonstrate, using a mutant form of Bcl6 with two BTB (bric-a-brac, tramtrack, broad-complex) mutations that abrogate corepressor binding, that the Bcl6 BTB domain is required for proper differentiation of Tfh and GC-Tfh cells in vivo. Importantly, we also observe a significant defect in GC B cell development. These results are consistent in multiple contexts, including a novel lymphocytic choriomeningitis virus nucleoprotein-specific TCR-transgenic mouse model. Taken together, these data suggest that the Bcl6 BTB domain is a key mediator of the differentiation of Tfh cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.