ArticleNeurobiology of learning and memory2016
Spatial pattern separation differences in older adult carriers and non-carriers for the apolipoprotein E epsilon 4 allele.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Optimizing the mnemonic similarity task for efficient, widespread use.Frontiers in behavioral neuroscience · 2023Article
- APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults.Hippocampus · 2021Article
- Spatial Pattern Separation Testing Differentiates Alzheimer's Disease Biomarker-Positive and Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults.NeuroImage · 2020Article
- Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity.Trends in cognitive sciences · 2019Review
- The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer's Disease Risk in African Americans: A Focused Mini Review.Frontiers in human neuroscience · 2019Article
- APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation.Neurobiology of aging · 2018Article
- Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss.Neuropsychologia · 2018Article
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Authors and funding
6 authors.
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Abstract
We examined the performance of healthy young (n=57) and older adults (n=43) genotyped as apolipoprotein E-ε4 (APOE-ε4) carriers or APOE-ε4 non-carriers on a delayed match-to-sample task involving varying degrees of spatial interference hypothesized to assess spatial pattern separation. Older adult ε4 carriers were further divided into "impaired" and "unimpaired" groups based on their performance on a standardized test of verbal memory. We found that performance on the spatial pattern separation test increased as a function of decreased spatial interference across all groups. The older ε4 carriers in the impaired group performed significantly worse (p<.05) than unimpaired ε4 carriers, ε4 non-carriers, and young adults. The data suggest that spatial pattern separation may be less efficient in a subset of healthy older adults with subtle memory decline who are carriers of the ε4 allele. However, pattern separation performance may be comparable to that of young adults in a subset of older adult ε4 carriers and more broadly among non-carriers. Our findings offer additional evidence that pattern separation may vary in older adults, and they provide novel insight into pattern separation efficiency in ε4-positive older adults.
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