ArticleEuropean radiology2016
Visual assessment of early emphysema and interstitial abnormalities on CT is useful in lung cancer risk analysis.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Associations between CT characteristics of lung cancer lesions and histologic subtypes in lung cancer screening.European radiology · 2026Article
- Early Functional Impairment in Smokers with CT-Detected Emphysema: Spirometry Provides Complementary Physiological Information in Lung Cancer Screening.Biomedicines · 2026Article
- Progression of interstitial lung abnormalities and its impact on mortality in patients with lung cancer resection.Chinese medical journal pulmonary and critical care medicine · 2026Article
- Deep learning-based lung cancer risk assessment using chest computed tomography images without pulmonary nodules ≥8 mm.Translational lung cancer research · 2025Article
- Interpretable machine learning model for digital lung cancer prescreening in Chinese populations with missing data.NPJ digital medicine · 2024Article
- Interstitial lung abnormality in COPD is inversely associated with the comorbidity of lung cancer.BMC pulmonary medicine · 2024Observational
- Systemic Determinants of Exercise Intolerance in Patients With Fibrotic Interstitial Lung Disease and Severely Impaired DRespiratory care · 2023Article
- ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- Article
- Lung function impairment in the German Lung Cancer Screening Intervention Study (LUSI): prevalence, symptoms, and associations with lung cancer risk, tumor histology and all-cause mortality.Translational lung cancer research · 2022Article
- Computed Tomography Features of Lung Structure Have Utility for Differentiating Malignant and Benign Pulmonary Nodules.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Incidental Findings on Low-Dose CT Scan Lung Cancer Screenings and Deaths From Respiratory Diseases.Chest · 2022Article
- Interstitial lung abnormalities: new insights between theory and clinical practice.Insights into imaging · 2022Review
- CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis.Journal of inflammation research · 2022Article
- Screen-detected solid nodules: from detection of nodule to structured reporting.Translational lung cancer research · 2021Review
- Lung cancer screening by nodule volume in Lung-RADS v1.1: negative baseline CT yields potential for increased screening interval.European radiology · 2021Article
- Interstitial lung abnormalities - current knowledge and future directions.European clinical respiratory journal · 2021Review
- Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images.Journal of clinical medicine · 2020Article
- The associations of interstitial lung abnormalities with cancer diagnoses and mortality.The European respiratory journal · 2020Article
- Regional emphysema score is associated with tumor location and poor prognosis in completely resected NSCLC patients.BMC pulmonary medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesScreening for lung cancer should be limited to a high-risk-population, and abnormalities in low-dose computed tomography (CT) screening images may be relevant for predicting the risk of lung cancer. Our aims were to compare the occurrence of visually detected emphysema and interstitial abnormalities in subjects with and without lung cancer in a screening population of smokers.
methodsLow-dose chest CT examinations (baseline and latest possible) of 1990 participants from The Danish Lung Cancer Screening Trial were independently evaluated by two observers who scored emphysema and interstitial abnormalities. Emphysema (lung density) was also measured quantitatively.
resultsEmphysema was seen more frequently and its extent was greater among participants with lung cancer on baseline (odds ratio (OR), 1.8, p = 0.017 and p = 0.002) and late examinations (OR 2.6, p < 0.001 and p < 0.001). No significant difference was found using quantitative measurements. Interstitial abnormalities were more common findings among participants with lung cancer (OR 5.1, p < 0.001 and OR 4.5, p < 0.001).There was no association between presence of emphysema and presence of interstitial abnormalities (OR 0.75, p = 0.499).
conclusionsEven early signs of emphysema and interstitial abnormalities are associated with lung cancer. Quantitative measurements of emphysema-regardless of type-do not show the same association. KEY POINTS: • Visually detected emphysema on CT is more frequent in individuals who develop lung cancer. • Emphysema grading is higher in those who develop lung cancer. • Interstitial abnormalities, including discrete changes, are associated with lung cancer. • Quantitative lung density measurements are not useful in lung cancer risk prediction. • Early CT signs of emphysema and interstitial abnormalities can predict future risk.
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