ArticleCirculation. Cardiovascular imaging2015
Dynamic phenotypes of degenerative myxomatous mitral valve disease: quantitative 3-dimensional echocardiographic study.
Article in Circulation. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Automatic transesophageal echocardiographic evaluation of patients with mitral valve prolapse: comparison with patients without structural cardiac chamber remodeling (an exploratory study).Journal of thoracic disease · 2026Article
- Automatic 4D mitral valve segmentation from transesophageal echocardiography: a semi-supervised learning approach.Medical & biological engineering & computing · 2026Article
- Effect of pimobendan on mitral annular dynamics and mitral regurgitation in dogs with myxomatous mitral valve disease as determined by cardiac computed tomography.Journal of veterinary internal medicine · 2026Article
- Sex-Based Differences in Mitral Annular Disjunction Severity and Arrhythmic Risk in Mitral Valve Prolapse.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026Article
- Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications.Scientific reports · 2024Article
- Two-dimensional transthoracic measure of mitral annulus in mitral valve prolapse and moderate to severe regurgitation: a method comparison analysis with three-dimensional transesophageal echocardiography.Journal of cardiovascular imaging · 2024Article
- Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications.Circulation. Cardiovascular imaging · 2024Article
- The Left Atrium: Passive Receptacle or Active Contributor to Mitral Regurgitation Severity and Outcome.JACC. Case reports · 2024Article
- Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.Circulation. Cardiovascular imaging · 2023Article
- Biology of mitral valve prolapse: from general mechanisms to advanced molecular patterns-a narrative review.Frontiers in cardiovascular medicine · 2023Review
- Histopathological insights into mitral valve prolapse-induced fibrosis.Frontiers in cardiovascular medicine · 2023Review
- Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel.Journal of the American College of Cardiology · 2022Review
- Mitral Valve Prolapse-The Role of Cardiac Imaging Modalities.Structural heart : the journal of the Heart Team · 2022Review
- Malignant Mitral Valve Prolapse: Risk and Prevention of Sudden Cardiac Death.Current treatment options in cardiovascular medicine · 2022Article
- Mitral prolapsing volume is associated with increased cardiac dimensions in patients with mitral annular disjunction.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2022Article
- Left Ventricular Remodeling in Non-syndromic Mitral Valve Prolapse: Volume Overload or Concomitant Cardiomyopathy?Frontiers in cardiovascular medicine · 2022Review
- Arrhythmias in Patients With Valvular Heart Disease: Gaps in Knowledge and the Way Forward.Frontiers in cardiovascular medicine · 2022Review
- Evolution from mitral annular dysfunction to severe mitral regurgitation in Barlow's disease.Interactive cardiovascular and thoracic surgery · 2021Article
- Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow's Disease.Journal of cardiovascular development and disease · 2021Review
- Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence.Journal of cardiovascular development and disease · 2021Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFibro-elastic deficiency (FED) and diffuse myxomatous degeneration (DMD) are phenotypes of degenerative mitral valve disease defined morphologically. Whether physiological differences in annular and valvular dynamics exist between these phenotypes remains unknown. METHODS AND
resultsWe performed triple quantitation of cardiac remodeling and of mitral regurgitation severity and of annular and valvular dimensions by real-time 3-dimensional-transesophageal-echocardiography. Forty-nine patients with degenerative mitral valve disease classified as FED (n=31) and DMD (n=18) by surgical observation showed no difference in age (65±10 versus 59±13; P=0.5), body surface area (2.0±0.2 versus 2.0±0.2 m(2); P=0.5), left ventricular and atrial dimensions (all P>0.55), and mitral regurgitation regurgitant orifice (P=0.62). On average, annular dimensions were larger in DMD versus FED, but height was similar resulting in lower saddle shape. Dynamically, annular DMD versus FED display poorer contraction and saddle-shape accentuation in early systole and abnormal enlargement, particularly intercommissural, in late-systole (all P<0.05). Valvular dynamics showed stable valvular area in systole in FED versus considerable systolic increased area in DMD (P<0.001). Prolapse height and volume increased little throughout systole in FED versus marked increase in DMD (P<0.001).
conclusionsOur novel observations show that FED and DMD, although both labeled myxomatous, display considerable physiological phenotypic differences. In DMD, the annular increased size and profoundly abnormal dynamics demonstrate DMD-specific annular degeneration compared with the enlarged but relatively normal FED annulus. DMD does not incur more severe mitral regurgitation, despite larger prolapse and valve redundancy, underscoring potential compensatory role of tissue redundancy of DMD (or aggravating role of tissue paucity of FED) on mitral regurgitation severity.
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