ArticleNeuroImage2015
Axon diameter and axonal transport: In vivo and in vitro effects of androgens.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms.Journal of child psychology and psychiatry, and allied disciplines · 2022Pooled it
- Pooled it
- White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research.Drug and alcohol dependence · 2016Pooled it
- Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fiber calibre, and vascularization.GeroScience · 2026Article
- Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.Journal of cachexia, sarcopenia and muscle · 2025Article
- White Matter Microstructure Among Straight and Gay Cisgender Men, Sao Praphet Song, and Straight Cisgender Women in Thailand.Human brain mapping · 2025Article
- Axonal structure-function relationships across experimental modalities.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Testosterone Reduces Myelin Abnormalities in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.Biomolecules · 2024Article
- Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons.Nature communications · 2024Article
- Large-Scale Population-Based Studies of Blood Metabolome and Brain Health.Current topics in behavioral neurosciences · 2024Review
- Handling Difficult Cryo-ET Samples: A Study with Primary Neurons from Drosophila melanogaster.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023Article
- Novel insights into axon diameter and myelin content in late childhood and adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Automated pipeline for nerve fiber selection and g-ratio calculation in optical microscopy: exploring staining protocol variations.Frontiers in neuroanatomy · 2023Article
- Sex and sensitive period differences in potential effects of maltreatment on axial versus radial diffusivity in the corpus callosum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients.American journal of cancer research · 2022Article
- Reduced Axon Calibre in the Associative Striatum of theBrain sciences · 2021Article
- Age-related estimates of aggregate g-ratio of white matter structures assessed using quantitative magnetic resonance neuroimaging.Human brain mapping · 2021Article
- Pubertal Testosterone and the Structure of the Cerebral Cortex in Young Men.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage.Developmental cognitive neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Testosterone is a sex hormone involved in brain maturation via multiple molecular mechanisms. Previous human studies described age-related changes in the overall volume and structural properties of white matter during male puberty. Based on this work, we have proposed that testosterone may induce a radial growth of the axon and, possibly, modulate axonal transport. In order to determine whether this is the case we have used two different experimental approaches. With electron microscopy, we have evaluated sex differences in the structural properties of axons in the corpus callosum (splenium) of young rats, and tested consequences of castration carried out after weaning. Then we examined in vitro the effect of the non-aromatizable androgen Mibolerone on the structure and bidirectional transport of wheat-germ agglutinin vesicles in the axons of cultured sympathetic neurons. With electron microscopy, we found robust sex differences in axonal diameter (males>females) and g ratio (males>females). Removal of endogenous testosterone by castration was associated with lower axon diameter and lower g ratio in castrated (vs. intact) males. In vitro, Mibolerone influenced the axonal transport in a time- and dose-dependent manner, and increased the axon caliber as compared with vehicle-treated neurons. These findings are consistent with the role of testosterone in shaping the axon by regulating its radial growth, as predicted by the initial human studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.