ArticlePediatric nephrology (Berlin, Germany)2015
A new serum cystatin C formula for estimating glomerular filtration rate in newborns.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- TIMP-2 and IGFBP7 for the differentiation of functional and intrinsic pediatric acute kidney injury.Pediatric research · 2026Article
- Cystatin C as a Renal Biomarker in Infants with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Glomerular Filtration Rate Assessment in Children.Children (Basel, Switzerland) · 2022Review
- Markers of Kidney Function in Early Childhood and Association With Maternal Comorbidity.JAMA network open · 2022Article
- Maturation of glomerular filtration rate in neonates and infants: an overview.Pediatric nephrology (Berlin, Germany) · 2021Review
- Cystatin C: A more reliable biomarker of renal function in young infants? A longitudinal cohort study.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates.Pediatric nephrology (Berlin, Germany) · 2021Article
- Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition.Nutrients · 2020Article
- Renal Precision Medicine in Neonates and Acute Kidney Injury: How to Convert a Cloud of Creatinine Observations to Support Clinical Decisions.Frontiers in pediatrics · 2020Review
- Association between cord blood cystatin C levels and early mortality of neonates with congenital abnormalities of the kidney and urinary tract: a single-center, retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2017Article
- Assessment of kidney function in preterm infants: lifelong implications.Pediatric nephrology (Berlin, Germany) · 2016Review
- Urinary biomarkers for the differentiation of prerenal and intrinsic pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2016Article
- Comparison between a serum creatinine-and a cystatin C-based glomerular filtration rate equation in patients receiving amphotericin B.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2016Article
- Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants.Pediatric nephrology (Berlin, Germany) · 2016Article
- A step forward towards accurately assessing glomerular filtration rate in newborns.Pediatric nephrology (Berlin, Germany) · 2015Article
- Article
- Glomerular Filtration Rate Estimation Formulas for Pediatric and Neonatal Use.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe levels of serum cystatin C (CysC) and creatinine (Cr) were determined in small-for-gestational-age (SGA) babies and compared with those for normal term newborns appropriate for gestational age (AGA), at birth and 3 days later. We then compared a number of cysC-based, Cr-based and combined formulas for estimation of glomerular filtration rate (GFR) with the neonatal reference GFR.
methodsFifty full-term SGA and 50 AGA newborns were enrolled in the study. Kidney volume measurements were performed by ultrasound for each newborn.
resultsAt birth, the mean level of CysC in SGA babies was 1.48 ± 0.30 mg/l in cord blood and 1.38 ± 0.18 mg/l in day 3 blood samples, and the mean Cr level, determined simultaneously, was 67.08 ± 17.62 and 55.62 ± 14.91 μmol/l, respectively. These levels did not differ significantly from those determined in AGA babies. A 10 % reduction in kidney volume was associated with an increase in CysC value of 9.3 % in cord blood. The Cr-based and Schwartz-combined equations underestimated GFR relative to CysC-based and Zappitelli-based equations at birth and 3 days later.
conclusionsA newly constructed Cys-C based formula which includes kidney volume and body surface area in the calculations for GFR is a reliable marker of GFR compared with neonatal reference clearance values.
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