ReviewExperimental biology and medicine (Maywood, N.J.)2015
Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification.
Review in Experimental biology and medicine (Maywood, N.J.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Review
- Modeling the pathophysiology of Parkinson's disease in patient-specific neurons.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons.Brain and behavior · 2019Article
- Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases.BMC biotechnology · 2019Article
- CRISPR/Cas9 targeting of the androgen receptor suppresses the growth of LNCaP human prostate cancer cells.Molecular medicine reports · 2018Article
- One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor.Scientific reports · 2017Article
- To CRISPR and beyond: the evolution of genome editing in stem cells.Regenerative medicine · 2016Review
- Genome editing: intellectual property and product development in plant biotechnology.Plant cell reports · 2016Review
- Gene Therapy for the Treatment of Primary Immune Deficiencies.Current allergy and asthma reports · 2016Review
- Gene Targeting Using Homologous Recombination in Embryonic Stem Cells: The Future for Behavior Genetics?Frontiers in genetics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The capability to modify the genome precisely and efficiently offers an extremely useful tool for biomedical research. Recent developments in genome editing technologies such as transcription activator-like effector nuclease and the clustered regularly interspaced short palindromic repeats system have made genome modification available for a number of organisms with relative ease. Here, we introduce these genome editing techniques, compare and contrast each technical approach and discuss their potential to study the underlying mechanisms of human disease using patient-derived induced pluripotent stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.