Trial reportAge (Dordrecht, Netherlands)2015
Neuronal mechanisms of motor learning and motor memory consolidation in healthy old adults.
Trial report in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive and Reactive Locomotor Adaptability in Healthy Elderly: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Compared motor learning effects of motor cortical and cerebellar repetitive transcranial magnetic stimulation during a serial reaction time task in older adults.Scientific reports · 2025Trial
- Early sleep after action observation and motor imagery training boosts improvements in manual dexterity.Scientific reports · 2023Trial
- Augmented feedback for manual wheelchair propulsion technique training in a virtual reality simulator.Journal of neuroengineering and rehabilitation · 2021Trial
- Functional performance comparison between real and virtual tasks in older adults: A cross-sectional study.Medicine · 2018Trial
- Increased corticospinal excitability after rest with short term motor performance.Experimental physiology · 2026Article
- Limited Evidence to Review-Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?NeuroSci · 2025Review
- Enhancing prehension strength and dexterity through cross-education effects in the elderly.Scientific reports · 2025Article
- Enhancing golf swing performance through M1-targeted transcranial direct current stimulation: a double-blind, randomized crossover study.Frontiers in sports and active living · 2025Article
- Influence of Voluntary Contraction Level, Test Stimulus Intensity and Normalization Procedures on the Evaluation of Short-Interval Intracortical Inhibition.Brain sciences · 2020Article
- Age-Dependent Effect of Transcranial Alternating Current Stimulation on Motor Skill Consolidation.Frontiers in aging neuroscience · 2020Article
- Use of imperceptible wrist vibration to modulate sensorimotor cortical activity.Experimental brain research · 2019Article
- Acute Exercise as an Intervention to Trigger Motor Performance and EEG Beta Activity in Older Adults.Neural plasticity · 2018Article
- Does physical activity benefit motor performance and learning of upper extremity tasks in older adults? - A systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2017Review
- Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.Age (Dordrecht, Netherlands) · 2016Article
- Motor Skill Acquisition and Retention after Somatosensory Electrical Stimulation in Healthy Humans.Frontiers in human neuroscience · 2016Article
- Endurance Exercise as an "Endogenous" Neuro-enhancement Strategy to Facilitate Motor Learning.Frontiers in human neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is controversial whether or not old adults are capable of learning new motor skills and consolidate the performance gains into motor memory in the offline period. The underlying neuronal mechanisms are equally unclear. We determined the magnitude of motor learning and motor memory consolidation in healthy old adults and examined if specific metrics of neuronal excitability measured by magnetic brain stimulation mediate the practice and retention effects. Eleven healthy old adults practiced a wrist extension-flexion visuomotor skill for 20 min (MP, 71.3 years), while a second group only watched the templates without movements (attentional control, AC, n = 11, 70.5 years). There was 40 % motor learning in MP but none in AC (interaction, p < 0.001) with the skill retained 24 h later in MP and a 16 % improvement in AC. Corticospinal excitability at rest and during task did not change, but when measured during contraction at 20 % of maximal force, it strongly increased in MP and decreased in AC (interaction, p = 0.002). Intracortical inhibition at rest and during the task decreased and facilitation at rest increased in MP, but these metrics changed in the opposite direction in AC. These neuronal changes were especially profound at retention. Healthy old adults can learn a new motor skill and consolidate the learned skill into motor memory, processes that are most likely mediated by disinhibitory mechanisms. These results are relevant for the increasing number of old adults who need to learn and relearn movements during motor rehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.