ArticleJournal of Crohn's & colitis2015
The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].
Article in Journal of Crohn's & colitis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Improving Endoscopic Scoring Accuracy in Pediatric Inflammatory Bowel Disease: Impact of a Focused Training Intervention.Endoscopy international open · 2026Article
- The Effectiveness of Huangkui Lianchang Decoction Enema Solution Compared with Mesalazine Enema for Mild-to-Moderate Active Distal Ulcerative Colitis: Study Protocol of a Multicenter, Prospective, Randomized Controlled Trial.Journal of pain research · 2026Article
- An Interpretable Artificial Intelligence System for Crohn's Disease Ulcer Identification and Grading on Double-Balloon Enteroscopy Images.United European gastroenterology journal · 2025Article
- The value of fecal calprotectin measured by fluorescent immunochromatography assay in evaluating clinical and endoscopic activity in ulcerative colitis.BMC gastroenterology · 2025Article
- Effectiveness and safety of upadacitinib in acute severe ulcerative colitis patients from single Chinese IBD Center: a monocentric study.Clinical and experimental medicine · 2024Article
- Deep mucosal healing in ulcerative colitis: how deep is better?Frontiers in medicine · 2024Review
- Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials.Journal of Crohn's & colitis · 2023Review
- Application of plasma alternative to serum for measuring leucine-rich α2-glycoprotein as a biomarker of inflammatory bowel disease.PloS one · 2023Observational
- Validation and Update of the Lémann Index to Measure Cumulative Structural Bowel Damage in Crohn's Disease.Gastroenterology · 2021Observational
- A Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis.Gastroenterology & hepatology · 2021Article
- Comparison of the Mayo Endoscopy Score and the Ulcerative Colitis Endoscopy Index of Severity and the Ulcerative Colitis Colonoscopy Index of Severity.Endoscopy international open · 2021Article
- Correlation between fecal calprotectin, ulcerative colitis endoscopic index of severity and clinical outcome in patients with acute severe colitis.Experimental and therapeutic medicine · 2020Article
- Correlation between Clinical Symptoms and Lab Tests with Endoscopic Severity Indexes in Patients with Inflammatory Bowel Diseases.Middle East journal of digestive diseases · 2020Article
- Relationship between Mayo endoscopic score and histological scores in ulcerative colitis: A prospective study.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Prevalence of endoscopic improvement and remission according to patient-reported outcomes in ulcerative colitis.Alimentary pharmacology & therapeutics · 2020Article
- The role of artificial intelligence in colon polyps detection.Gastroenterology and hepatology from bed to bench · 2020Review
- The Role of Bowel Ultrasound in Detecting Subclinical Inflammation in Pregnant Women with Crohn's Disease.Journal of the Canadian Association of Gastroenterology · 2019Article
- Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission.World journal of clinical cases · 2018Article
- Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis.Journal of Crohn's & colitis · 2018Article
- Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Score (MES) in guiding the need for colectomy in patients with acute severe colitis.Gastroenterology report · 2018Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsTo determine whether clinical information influences endoscopic scoring by central readers using the Ulcerative Colitis Endoscopic Index of Severity [UCEIS; comprising 'vascular pattern', 'bleeding', 'erosions and ulcers'].
methodsForty central readers performed 28 evaluations, including 2 repeats, from a library of 44 video sigmoidoscopies stratified by Mayo Clinic Score. Following training, readers were randomised to scoring with ['unblinded', n = 20, including 4 control videos with misleading information] or without ['blinded', n 20] clinical information. A total of 21 virtual Central Reader Groups [CRGs], of three blinded readers, were created. Agreement criteria were pre-specified. Kappa [κ] statistics quantified intra- and inter-reader variability.
resultsMean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos. UCEIS standard deviations [SD] were similar [median blinded 0.94, unblinded 0.93; p = 0.97]. Correlation between UCEIS and visual analogue scale [VAS] assessment of overall severity was high [r blinded = 0.90, unblinded = 0.93; p = 0.02]. Scores for control videos were similar [UCEIS: p ≥ 0.55; VAS: p ≥ 0.07]. Intra- [κ 0.47-0.74] and inter-reader [κ 0.40-0.53] variability for items and full UCEIS was 'moderate'-to-'substantial', with no significant differences except for intra-reader variability for erosions and ulcers [κ blinded: 0.47 vs unblinded: 0.74; p 0.047]. The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001]. Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81].
conclusionsThe UCEIS is minimally affected by knowledge of clinical details, strongly correlates with patient-reported symptoms, and is a suitable instrument for trials. CRGs performed better than individuals.
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