Observational studyJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2015
Electrolyte and hemodynamic changes following percutaneous left atrial appendage ligation with the LARIAT device.
Observational study in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Percutaneous versus thoracoscopic ablation of symptomatic paroxysmal atrial fibrillation: a randomised controlled trial - the FAST II study.Journal of cardiothoracic surgery · 2018Trial
- Severe orthostatic hypotension after left atrial appendage occlusion.HeartRhythm case reports · 2026Article
- The Efficacy of Left Atrial Appendage Occlusion During Thoracoscopic Epicardial AF Ablation for Improving Rhythm and Cardiac Function in Patients With Heart Failure.Journal of arrhythmia · 2026Article
- Effects of Left Atrial Appendage Closure on Neuroendocrine Function in Patients with Nonvalvular Atrial Fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Left Atrial Appendage Closure: A Current Overview Focused on Technical Aspects and Different Approaches.Reviews in cardiovascular medicine · 2022Review
- Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis:Journal of clinical medicine · 2022Article
- The Convergent Ablation and AtriClip Exclusion of the Left Atrial Appendage in Long-Standing Persistent Atrial Fibrillation.Clinical medicine insights. Case reports · 2022Article
- Surgical clip closure of the left atrial appendage.Journal of cardiovascular electrophysiology · 2021Review
- Left atrial appendage-beyond being a thrombus-spreading tiger.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018Article
- Cardiovascular Therapies Targeting Left Atrial Appendage.Journal of the American College of Cardiology · 2018Review
- Left Atrial Appendage Occlusion: What Are the Options and Where is the Evidence?The Journal of innovations in cardiac rhythm management · 2018Review
- Is there an alternative treatment for patients intolerant to antiplatelet therapy if percutaneous left atrial appendage closure is considered?Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2017Article
- Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP.Scientific reports · 2017Observational
- Five years of keeping a watch on the left atrial appendage-how has the WATCHMAN fared?Journal of thoracic disease · 2016Article
- Simultaneous appendage ligation and atrial ablation - is it worth the risk?Indian pacing and electrophysiology journalArticle
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe left atrial appendage (LAA) is a well-known source of atrial natriuretic peptide (ANP) and therefore plays an important role in homeostasis. The neurohormonal impact of epicardial exclusion of the LAA with the LARIAT procedure is unknown. In this proof-of-concept study, we postulated that LAA exclusion would impact homeostasis as evidenced by changes in electrolytes and blood pressure (BP).
methodsA total of 76 patients who underwent successful LAA exclusion were enrolled in this retrospective observational study utilizing a prospective registry. Electrolytes, BP, and heart rate (HR) were monitored before LARIAT and post-LARIAT (24 and 72 h and 6 months).
resultsThere was a significant reduction of systolic BP (mmHg) at 24 h (113.3 ± 16.0; p < 0.0001) and 72 h (119.0 ± 18.4 mmHg; p < 0.0001) post-LARIAT when compared with pre-LARIAT BP (138.2 ± 21.3). The reduction in systolic BP persisted at 6-month follow-up (128.8 ± 17.3; p = 0.0005). There was significant reduction in serum sodium (mmol/L) at 24 h (135.4 ± 3.6; p < 0.0001) and 72 h (136.3 ± 3.7; p < 0.001) post-LARIAT when compared to pre-LARIAT (138.7 ± 3.2). The reduction in sodium was not persistent at 6-month follow-up (138.4 ± 3.3; p = 0.453).
conclusionsLAA exclusion results in an early and persistent decrease in systolic BP. Additionally, there is an early decline in serum sodium, which normalizes at long-term follow-up. The underlying mechanism leading to these changes is not entirely clear; however, it is likely related to neurohormonal changes post LAA exclusion.
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