ReviewFertility and sterility2015
Paternal age and mental health of offspring.
Review in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- Relationship between degree of methylation of sperm long interspersed nuclear element-1 (LINE-1) gene and alteration of sperm parameters and age: a meta-regression analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Prenatal ambient temperature and risk for schizophrenia.Schizophrenia research · 2022Pooled it
- Article
- Does SpermBiomedicines · 2024Review
- Comparison of early risk factors between healthy siblings and subjects with schizophrenia and bipolar disorder.Frontiers in psychiatry · 2024Article
- Effects of paternal and chronological age onAging · 2023Article
- From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology.Medicina (Kaunas, Lithuania) · 2023Review
- Reproductive axis ageing and fertility in men.Reviews in endocrine & metabolic disorders · 2022Review
- Association between parental age, brain structure, and behavioral and cognitive problems in children.Molecular psychiatry · 2022Article
- Advanced Paternal Age and Future Generations.Frontiers in endocrinology · 2022Review
- Social, demographic and health characteristics of men fathering children at different ages.Scientific reports · 2021Article
- Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.Schizophrenia research · 2021Review
- An exploratory analysis of the relationship between paternal age at pregnancy and difficulties symptomatic of specific learning disorders among Japanese undergraduate students.Journal of rural medicine : JRM · 2021Article
- Association between paternal age and risk of schizophrenia: a nationwide population-based study.Journal of assisted reproduction and genetics · 2021Article
- Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.Biomedical reports · 2020Article
- Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?International journal of mental health systems · 2020Review
- Consanguineous Marriage and the Psychopathology of Progeny: A Population-wide Data Linkage Study.JAMA psychiatry · 2018Observational
- Paternal age effects on sperm FOXK1 and KCNA7 methylation and transmission into the next generation.Human molecular genetics · 2016Article
- The maternal body as environment in autism science.Social studies of science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The influence of paternal age on the risk for sporadic forms of Mendelian disorders is well known, but a burgeoning recent literature demonstrates, in addition, a paternal age effect for complex neuropsychiatric conditions, including schizophrenia, autism, bipolar disorder, and even for learning potential, expressed as intelligence. Mental illness is costly to patients, their family, and the public health system, accounting for the largest portion of disability costs in our economy. The delayed onset of neuropsychiatric conditions and lack of physical manifestations at birth are common frequencies in the population that have obscured the recognition that a portion of the risks for mental conditions is associated with paternal age. Identification of these risk pathways may be leveraged for knowledge about mental function and for future screening tests. However, only a small minority of at-risk offspring are likely to have such a psychiatric or learning disorder attributable to paternal age, including the children of older fathers.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.