Trial reportFertility and sterility2015
Adverse pregnancy outcomes after in vitro fertilization: effect of number of embryos transferred and plurality at conception.
Trial report in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The impact of single-step and sequential embryo culture systems on obstetric and perinatal outcomes in singleton pregnancies: the Massachusetts Outcomes Study of Assisted Reproductive Technology.Fertility and sterility · 2022Article
- The Maternal-Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Risks of nonchromosomal birth defects, small-for-gestational age birthweight, and prematurity with in vitro fertilization: effect of number of embryos transferred and plurality at conception versus at birth.Journal of assisted reproduction and genetics · 2021Article
- Number of embryos transferred and diagnosis of preeclampsia.Reproductive biology and endocrinology : RB&E · 2020Article
- Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study.BMC pregnancy and childbirth · 2020Article
- Hospitalization before and after delivery in fertile, subfertile, and ART-treated women.Journal of assisted reproduction and genetics · 2019Article
- Article
- Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology.American journal of obstetrics and gynecology · 2017Article
- Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology.American journal of obstetrics and gynecology · 2017Article
- Pregnancy and birth outcomes in couples with infertility with and without assisted reproductive technology: with an emphasis on US population-based studies.American journal of obstetrics and gynecology · 2017Review
- Inpatient hospitalizations in women with and without assisted reproductive technology live birth.Journal of assisted reproduction and genetics · 2017Article
- Perinatal outcomes among singletons after assisted reproductive technology with single-embryo or double-embryo transfer versus no assisted reproductive technology.Fertility and sterility · 2017Article
- Perinatal outcomes of singleton siblings: the effects of changing maternal fertility status.Journal of assisted reproduction and genetics · 2016Article
- Factors associated with the use of elective single-embryo transfer and pregnancy outcomes in the United States, 2004-2012.Fertility and sterility · 2016Article
- Severe Maternal Morbidity and the Use of Assisted Reproductive Technology in Massachusetts.Obstetrics and gynecology · 2016Article
- Is the wrong question being asked in infertility research?Journal of assisted reproduction and genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo evaluate risks for adverse pregnancy outcomes by number of embryos transferred (ET) and fetal heartbeats (FHB) in assisted reproductive technology-conceived singleton live births.
designLongitudinal cohort using cycles reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System between 2004 and 2008 among women who were treated and gave birth in Massachusetts.
settingNot applicable. PATIENT(S): Assisted reproductive technology data on 6,073 births between 2004 and 2008 were linked to vital records and hospital data. Likelihood of ET ≥3 vs. 1-2, FHB >1 vs. 1, and risks of preterm birth (PTB, <37 weeks' gestation), low birth weight (LBW, <2,500 g), and small-for-gestational-age birth weight (SGA, <10th percentile) with FHB >1 were modeled with binary logistic regression using a backward-stepping algorithm, and presented as adjusted odds ratios (95% confidence intervals). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): ET ≥3, FHB >1, PTB, LBW, and SGA. RESULT(S): Higher ET was significantly more likely with older maternal age, intracytoplasmic sperm injection, assisted hatching, cleavage-stage embryos, and thawed embryos. The likelihood of FHB >1 with ≥3 ET vs. 1-2 ET was 2.04 (1.68-2.48). Risks of PTB and LBW with FHB >1 were 1.63 (1.27-2.09) and 1.81 (1.36-2.39), respectively; the risk of SGA was not significant. Nulliparity was associated with higher risks of PTB (1.34 [1.12-1.59]), LBW (1.48 [1.20-1.83]), and SGA (2.17 [1.69-2.78]). CONCLUSION(S): Number of embryos transferred was strongly associated with FHBs, with twice the risk of FHB >1 with ≥3 ET vs. 1-2 ET. Increasing FHBs were associated with significantly greater risks for PTB and LBW outcomes.
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