ArticleJournal of assisted reproduction and genetics2015
Assessment of aneuploidy formation in human blastocysts resulting from donated eggs and the necessity of the embryos for aneuploidy screening.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Decision making of male same-sex couples pursuing pregnancy via assisted reproductive technology: a qualitative study.F&S reports · 2025Article
- Assessing the impact of both preimplantation genetic testing for aneuploidy with blastocyst morphologic grade on live birth rates in frozen embryo transfers from fresh and frozen donor oocytes.Archives of gynecology and obstetrics · 2025Article
- OneGene PGT: comprehensive preimplantation genetic testing method utilizing next-generation sequencing.Journal of assisted reproduction and genetics · 2024Article
- The correlation between morphological parameters and the incidence of de novo chromosomal abnormalities in 3238 biopsied blastocysts.Journal of assisted reproduction and genetics · 2023Article
- Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles.Scientific reports · 2023Article
- Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation.Science advances · 2022Article
- The effect of ovarian stimulation on aneuploidy of early aborted tissues and preimplantation blastocysts: comparison of the GnRH agonist long protocol with the GnRH antagonist protocol.Journal of assisted reproduction and genetics · 2022Article
- Results of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in a Cohort of 319 Embryos: Experience in a Fertility Clinic in Colombia.JBRA assisted reproduction · 2022Observational
- Influence of Trophectoderm Biopsy Prior to Frozen Blastocyst Transfer on Obstetrical Outcomes.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Preimplantation genetic testing for aneuploidies does not increase success rates in fresh oocyte donation cycles: a paired cohort study.Journal of assisted reproduction and genetics · 2021Article
- Cost-effectiveness of preimplantation genetic testing for aneuploidy for fresh donor oocyte cycles.F&S reports · 2021Article
- Transfer the best and biopsy the rest? Blastocyst euploidy rates differ by morphology and day of biopsy.Archives of gynecology and obstetrics · 2021Article
- Donor oocyte recipients do not benefit from preimplantation genetic testing for aneuploidy to improve pregnancy outcomes.Human reproduction (Oxford, England) · 2020Article
- Preimplantation genetic testing and chances of a healthy live birth amongst recipients of fresh donor oocytes in the United States.Journal of assisted reproduction and genetics · 2020Article
- Preimplantation Genetic Testing: Where We Are Today.International journal of molecular sciences · 2020Review
- Euploid rates among oocyte donors: is there an optimal age for donation?Journal of assisted reproduction and genetics · 2020Article
- Does ICSI for in vitro fertilization cause more aneuploid embryos?Molecular cytogenetics · 2020Article
- Contraction behaviour reduces embryo competence in high-quality euploid blastocysts.Journal of assisted reproduction and genetics · 2018Article
- High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles.JBRA assisted reproduction · 2018Article
- Earlier day of blastocyst development is predictive of embryonic euploidy across all ages: essential data for physician decision-making and counseling patients.Journal of assisted reproduction and genetics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the prevalence of aneuploidy in human blastocysts resulting from donated eggs and embryo implantation after transfer of normal euploid embryos. Also, to assess the necessity of preimplantation genetic screening (PGS) for embryos produced with donor eggs.
methodsBlastocysts from donor-recipient cycles were biopsied for PGS (PGS group) and the samples were analyzed with DNA microarray. Euploid blastocysts were transferred to the recipients, and both clinical pregnancy and embryo implantation were examined and compared with embryos without PGS (control group).
resultsAfter PGS, 39.1 % of blastocysts were abnormal, including aneuploidy and euploid with partial chromosome deletion and/or duplication. Transfer of normal euploid blastocysts brought about 72.4 % of clinical pregnancy, 65.5 % of ongoing/delivery and 54.9 % of embryo implantation rates; these rates were slightly higher than those in the control group (66.7, 54.0 and 47.8 %, respectively), but there was no statistical difference between the two groups. By contrast, the miscarriage rate was higher in the control group (19.2 %) than in the PGS group (9.5 %), but no statistical difference was observed. Transfer of two or more embryos did not significantly increase the ongoing/delivery rates in both groups, but significantly increased the twin pregnancy rates (50.0 % in the PGS group and 43.8 % in the control group). CONCLUSION(S): High proportions of human blastocysts derived from donor eggs are aneuploid. Although pregnancy and embryo implantation rates were increased, and miscarriage rates were reduced by transfer of embryos selected by PGS, the efficiency was not significantly different as compared to the control, suggesting that PGS may be necessary only in some specific situations, such as single embryo transfer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.