ArticleEnvironmental health perspectives2015
Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
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Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.Particle and fibre toxicology · 2025Pooled it
- Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review.International journal of molecular sciences · 2024Pooled it
- A Systematic Review of the Placental Translocation of Micro- and Nanoplastics.Current environmental health reports · 2023Pooled it
- Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies.Particle and fibre toxicology · 2020Pooled it
- Human Exposure to Micro- and Nanoplastics:Environment & health (Washington, D.C.) · 2026Review
- New approach methodologies in nanomedicine: bridging the gap betweenChemical Society reviews · 2026Review
- Micro- and nanoplastics in pediatric health: from placental transfer to neurodevelopmental outcomes.Pediatric research · 2026Review
- Article
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- Emerging role of microplastics and nanoplastics in children's health.Pediatric research · 2026Review
- Health Risks of Prenatal and Early-Life Microplastics Exposure: A Comprehensive Review.Environment & health (Washington, D.C.) · 2026Review
- Adolescent exposure to polystyrene nanoplastics induces male reproductive damage via the microbiome-gut-testis axis.Journal of nanobiotechnology · 2026Article
- Polystyrene microplastics internalization by term placental chorionic villi explants.Placenta · 2026Review
- Current approaches and advances in placental toxicology.Trends in endocrinology and metabolism: TEM · 2026Review
- Microplastic exposure and human health risks across the life cycle: a focus on reproduction, development, and aging.Frontiers in cell and developmental biology · 2026Review
- Size-dependent translocation of polystyrene nanoplastics across biological barriers in mammals.Nature communications · 2025Article
- Toxicity of High-Density Polyethylene Nanoparticles in Combination with Silver Nanoparticles to Caco-2 and HT29MTX Cells Growing in 2D or 3D Culture.Molecules (Basel, Switzerland) · 2025Article
- Microplastics and child health: A scoping review of prenatal and early-life exposure routes and potential health risks.Toxicology reports · 2025Review
- Environmental Toxicants in the Hispanic Community Epigenetically Contributing to Preeclampsia.Cardiovascular toxicology · 2025Review
- Micro- and Nanoplastics and the Oral Cavity: Implications for Oral and Systemic Health, Dental Practice, and the Environment-A Narrative Review.Journal of functional biomaterials · 2025Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and in vitro studies have shown that nanoparticles can have potential toxic effects. However, nanoparticles also offer the opportunity to develop new therapeutic strategies to treat specifically either the pregnant mother or the fetus. Previous studies mainly addressed whether nanoparticles are able to cross the placental barrier. However, the transport mechanisms underlying nanoparticle translocation across the placenta are still unknown.
objectivesIn this study we examined which transport mechanisms underlie the placental transfer of nanoparticles.
methodsWe used the ex vivo human placental perfusion model to analyze the bidirectional transfer of plain and carboxylate modified polystyrene particles in a size range between 50 and 300 nm.
resultsWe observed that the transport of polystyrene particles in the fetal to maternal direction was significantly higher than for the maternal to fetal direction. Regardless of their ability to cross the placental barrier and the direction of perfusion, all polystyrene particles accumulated in the syncytiotrophoblast of the placental tissue.
conclusionsOur results indicate that the syncytiotrophoblast is the key player in regulating nanoparticle transport across the human placenta. The main mechanism underlying this translocation is not based on passive diffusion, but is likely to involve an active, energy-dependent transport pathway. These findings will be important for reproductive toxicology as well as for pharmaceutical engineering of new drug carriers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.