Evidence map›Paper›PMID 25955984›Full record

ArticleIEEE transactions on bio-medical engineering2015

Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry.

Siyu Chen, Ji Yi, Wenzhong Liu, Vadim Backman, Hao F Zhang

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Designing visible-light optical coherence tomography towards clinics.Quantitative imaging in medicine and surgery · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Visible-light optical coherence tomography: a review.Journal of biomedical optics · 2017
    Review
  13. Review
  14. Article
  15. Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Siyu Chen
Ji Yi
Wenzhong Liu
Vadim Backman
Hao F Zhang
Northwestern University · USNorthwestern University · PH

Funding

Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Multimodal Retinal Functional Imaging for Diabetic RetinopathyR01EY019951 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAWZI, AMANI A, JIAO, SHULIANG · 2011 to 2015
$3.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
NEI NIH HHS 1R01EY019951NEI NIH HHS 1R24EY022883NEI NIH HHS R01 EY019951NEI NIH HHS R24 EY022883NIDDK NIH HHS DP3 DK108248
6 · The paper itself

Abstract

Optical coherence tomography (OCT) oximetry explores the possibility to measure retinal hemoglobin oxygen saturation level (sO2). We investigated the accuracy of OCT retinal oximetry using Monte Carlo simulation in a commonly used four-layer retinal model. After we determined the appropriate number of simulated photon packets, we studied the effects of blood vessel diameter, signal sampling position, physiological sO2 level, and the blood packing factor on the accuracy of sO2 estimation in OCT retinal oximetry. The simulation results showed that a packing factor between 0.2 and 0.4 yields a reasonably accurate estimation of sO2 within a 5% error tolerance, which is independent of vessel diameter and sampling position, when visible-light illumination is used in OCT. We further explored the optimal optical spectral range for OCT retinal oximetry. The simulation results suggest that visible spectral range around 560 nm is better suited than near-infrared spectral range around 800 nm for OCT oximetry to warrant accurate measurements.

Indexed as

Signal Processing, Computer-AssistedHumansImage Processing, Computer-AssistedMonte Carlo MethodOximetryRetinaRetinal VesselsTomography, Optical Coherence

Identifiers

PMID25955984
PMCPMC4783381
OpenAlexW1536522980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.