ArticleAnesthesiology2015
Critical Changes in Cortical Neuronal Interactions in Anesthetized and Awake Rats.
Article in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.Neuroscience · 2025Article
- Microstimulation reveals anesthetic state-dependent effective connectivity of neurons in cerebral cortex.Frontiers in neuroscience · 2024Article
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia.iScience · 2022Article
- Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling.Neuroscience · 2021Article
- Altered stimulus representation in rat auditory cortex is not causal for loss of consciousness under general anaesthesia.British journal of anaesthesia · 2018Article
- Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Activation of Parvalbumin-Positive Neurons in Both Retina and Primary Visual Cortex Improves the Feature-Selectivity of Primary Visual Cortex Neurons.Neuroscience bulletin · 2017Article
- Neural Correlates of Consciousness at Near-Electrocerebral Silence in an Asphyxial Cardiac Arrest Model.Brain connectivity · 2017Article
- Repertoire of mesoscopic cortical activity is not reduced during anesthesia.Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeuronal interactions are fundamental for information processing, cognition, and consciousness. Anesthetics reduce spontaneous cortical activity; however, neuronal reactivity to sensory stimuli is often preserved or augmented. How sensory stimulus-related neuronal interactions change under anesthesia has not been elucidated. In this study, the authors investigated the visual stimulus-related cortical neuronal interactions during stepwise emergence from desflurane anesthesia.
methodsParallel spike trains were recorded with 64-contact extracellular microelectrode arrays from the primary visual cortex of chronically instrumented, unrestrained rats (N = 6) at 8, 6, 4, and 2% desflurane anesthesia and wakefulness. Light flashes were delivered to the retina by transcranial illumination at 5- to 15-s randomized intervals. Information theoretical indices, integration and interaction complexity, were calculated from the probability distribution of coincident spike patterns and used to quantify neuronal interactions before and after flash stimulation.
resultsIntegration and complexity showed significant negative associations with desflurane concentration (N = 60). Flash stimulation increased integration and complexity at all anesthetic levels (N = 60); the effect on complexity was reduced in wakefulness. During stepwise withdrawal of desflurane, the largest increase in integration (74%) and poststimulus complexity (35%) occurred before reaching 4% desflurane concentration-a level associated with the recovery of consciousness according to the rats' righting reflex.
conclusionsNeuronal interactions in the cerebral cortex are augmented during emergence from anesthesia. Visual flash stimuli enhance neuronal interactions in both wakefulness and anesthesia; the increase in interaction complexity is attenuated as poststimulus complexity reaches plateau. The critical changes in cortical neuronal interactions occur during transition to consciousness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.