ArticleeLife2015
Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca²⁺ signaling.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Frizzled2 receives WntA signaling during butterfly wing pattern formation.Development (Cambridge, England) · 2023Article
- Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division.Nature cell biology · 2023Article
- A novel post-developmental role of the Hox genes underlies normal adult behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila.Disease models & mechanisms · 2021Article
- Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.Neurobiology of disease · 2020Article
- Loss ofFrontiers in neurology · 2020Article
- A Model for Basic Emotions Using Observations of Behavior inFrontiers in psychology · 2019Review
- Microtubules Stabilization by Mutant Spastin Affects ER Morphology and CaFrontiers in physiology · 2019Article
- FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster.PLoS genetics · 2018Article
- Flight and Climbing Assay for Assessing Motor Functions inBio-protocol · 2018Article
- Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.PLoS genetics · 2018Article
- Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons inFrontiers in systems neuroscience · 2018Article
- Sedentary behavior and altered metabolic activity by AgNPs ingestion in Drosophila melanogaster.Scientific reports · 2017Article
- A new brain dopamine-deficient Drosophila and its pharmacological and genetic rescue.Genes, brain, and behavior · 2017Article
- Spontaneous CaFrontiers in molecular neuroscience · 2017Article
- A decision underlies phototaxis in an insect.Open biology · 2016Article
- Caffeine promotes wakefulness via dopamine signaling in Drosophila.Scientific reports · 2016Article
- Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. Here, we demonstrate a requirement for Fz2/Ca(2+) signaling in determining the final differentiated state of a set of central brain dopaminergic neurons in Drosophila, referred to as the protocerebral anterior medial (PAM) cluster. Knockdown or inhibition of Fz2/Ca(2+) signaling during maturation of the flight circuit in pupae reduces Tyrosine Hydroxylase (TH) expression in the PAM neurons and affects maintenance of flight. Thus, we demonstrate that Fz2/Ca(2+) transients during development serve as a pre-requisite for normal adult behavior. Our results support a neural mechanism where PAM neuron send projections to the α' and β' lobes of a higher brain centre, the mushroom body, and function in dopaminergic re-inforcement of flight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.