ArticlePloS one2015
Auditory mismatch negativity and repetition suppression deficits in schizophrenia explained by irregular computation of prediction error.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.Schizophrenia research · 2018Pooled it
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Perturbed sensory memory associated with schizotypy symptom load.Schizophrenia research · 2026Article
- Article
- Weaker top-down cognitive control and stronger bottom-up signaling transmission as a pathogenesis of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- The Use of Mismatch Negativity in Conjunction with Neuropsychological Tests to Discriminate Alzheimer's Dementia, Mild Cognitive Impairment and Healthy Aging.Noro psikiyatri arsivi · 2025Article
- Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis.Biological psychiatry global open science · 2025Article
- Habituation, Adaptation and Prediction Processes in Neurodevelopmental Disorders: A Comprehensive Review.Brain sciences · 2023Review
- Correlation of motor-auditory cross-modal and auditory unimodal N1 and mismatch responses of schizophrenic patients and normal subjects: an MEG study.Frontiers in psychiatry · 2023Article
- Mismatch negativity generation in subjects at risk for psychosis: source analysis is more sensitive than surface electrodes in risk prediction.Frontiers in psychiatry · 2023Article
- It's in the Timing: Reduced Temporal Precision in Neural Activity of Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The Adaptation Model Offers a Challenge for the Predictive Coding Account of Mismatch Negativity.Frontiers in human neuroscience · 2021Article
- Associations of mismatch negativity with psychotic symptoms and functioning transdiagnostically across psychotic disorders.Journal of abnormal psychology · 2020Article
- Making Sense of Mismatch Negativity.Frontiers in psychiatry · 2020Review
- Hyper-Activated Brain Resting-State Network and Mismatch Negativity Deficit in Schizophrenia With Auditory Verbal Hallucination Revealed by an Event-Related Potential Evidence.Frontiers in psychiatry · 2020Article
- Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia.Frontiers in pharmacology · 2020Review
- Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosisJournal of psychiatry & neuroscience : JPN · 2019Review
- Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping.NeuroImage. Clinical · 2019Article
- Knowing when to stop: Aberrant precision and evidence accumulation in schizophrenia.Schizophrenia research · 2018Article
- Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders.Scientific reports · 2017Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundThe predictive coding model is rapidly gaining attention in schizophrenia research. It posits the neuronal computation of residual variance ('prediction error') between sensory information and top-down expectation through multiple hierarchical levels. Event-related potentials (ERP) reflect cortical processing stages that are increasingly interpreted in the light of the predictive coding hypothesis. Both mismatch negativity (MMN) and repetition suppression (RS) measures are considered a prediction error correlates based on error detection and error minimization, respectively.
methodsTwenty-five schizophrenia patients and 25 healthy controls completed auditory tasks designed to elicit MMN and RS responses that were investigated using repeated measures models and strong spatio-temporal a priori hypothesis based on previous research. Separate correlations were performed for controls and schizophrenia patients, using age and clinical variables as covariates.
resultsMMN and RS deficits were largely replicated in our sample of schizophrenia patients. Moreover, MMN and RS measures were strongly correlated in healthy controls, while no correlation was found in schizophrenia patients. Single-trial analyses indicated significantly lower signal-to-noise ratio during prediction error computation in schizophrenia.
conclusionsThis study provides evidence that auditory ERP components relevant for schizophrenia research can be reconciled in the light of the predictive coding framework. The lack of any correlation between the investigated measures in schizophrenia patients suggests a disruption of predictive coding mechanisms in general. More specifically, these results suggest that schizophrenia is associated with an irregular computation of residual variance between sensory input and top-down models, i.e. prediction error.
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