Evidence map›Paper›PMID 25955833›Full record

ArticleThe Pediatric infectious disease journal2015

Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella.

James Kelley, Debra Tristram, Masaki Yamada, Charles Grose

Abstract readCase Reports
In one paragraph

Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James KelleyFrom the *Division of Pediatric Infectious Diseases, Albany Medical College, Albany New York; and †Division of Infectious Diseases/Virology, Children's Hospital, University of Iowa, Iowa City, Iowa.
Debra Tristram
Masaki Yamada
Charles Grose

Funding

Autophagy and ER stress during varicella infectionR01AI089716 · NIAID · UNIVERSITY OF IOWA · PI GROSE, CHARLES F. · 2011 to 2015
$1.9M
NIAID NIH HHS AI89716NIAID NIH HHS R01 AI089716
6 · The paper itself

Abstract

We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated.

Indexed as

Immunization ScheduleImmunocompromised HostAcyclovirAdolescentAntiviral AgentsChickenpoxChickenpox VaccineChild, PreschoolFatal OutcomeFemaleHumansMaleNeoplasmsAcyclovirAntiviral AgentsChickenpox Vaccine

Identifiers

PMID25955833
PMCPMC4532322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.