ArticlePloS one2015
Drosophila ovipositor extension in mating behavior and egg deposition involves distinct sets of brain interneurons.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 84 citations in OpenAlex.
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- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
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- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Ancestral neural circuits potentiate the origin of a female sexual behavior in Drosophila.Nature communications · 2024Article
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- Ancestral neural circuits potentiate the origin of a female sexual behavior.bioRxiv : the preprint server for biology · 2023Article
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- Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila.Nature neuroscience · 2023Article
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- Is the Natural Instinct to Oviposit in Mated Female Oriental Fruit Fly,Frontiers in physiology · 2022Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
- Flexibility of neural circuits regulating mating behaviors in mice and flies.Frontiers in neural circuits · 2022Review
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Oviposition is a female-specific behavior that directly affects fecundity, and therefore fitness. If a fertilized female encounters another male that she has evaluated to be of better quality than her previous mate, it would be beneficial for her to remate with this male rather than depositing her eggs. Females who decided not to remate exhibited rejection behavior toward a courting male and engaged in oviposition. Although recent studies of Drosophila melanogaster identified sensory neurons and putative second-order ascending interneurons that mediate uterine afferents affecting female reproductive behavior, little is known about the brain circuitry that selectively activates rejection versus oviposition behaviors. We identified the sexually dimorphic pC2l and female-specific pMN2 neurons, two distinct classes of doublesex (dsx)-expressing neurons that can initiate ovipositor extension associated with rejection and oviposition behavior, respectively. pC2l interneurons, which induce ovipositor extrusion for rejection in females, have homologues that control courtship behavior in males. Activation of these two classes of neurons appears to be mutually exclusive and each governs hierarchical control of the motor program in the VNC either for rejection or oviposition, contributing centrally to the switching on or off of the alternative motor programs.
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