ArticleJournal of the mechanical behavior of biomedical materials2015
Derivation of inter-lamellar behaviour of the intervertebral disc annulus.
Article in Journal of the mechanical behavior of biomedical materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Role of intra-lamellar collagen and hyaluronan nanostructures in annulus fibrosus on lumbar spine biomechanics: insights from molecular mechanics-finite element-based multiscale analyses.Medical & biological engineering & computing · 2025Article
- Elastic Fibers in the Intervertebral Disc: From Form to Function and toward Regeneration.International journal of molecular sciences · 2022Review
- Architecture-Promoted Biomechanical Performance-Tuning of Tissue-Engineered Constructs for Biological Intervertebral Disc Replacement.Materials (Basel, Switzerland) · 2021Article
- Sensitivity of Intervertebral Disc Finite Element Models to Internal Geometric and Non-geometric Parameters.Frontiers in bioengineering and biotechnology · 2021Article
- Using inverse finite element analysis to identify spinal tissue behaviour in situ.Methods (San Diego, Calif.) · 2021Article
- Interlamellar matrix governs human annulus fibrosus multiaxial behavior.Scientific reports · 2020Article
- Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach.Biomechanics and modeling in mechanobiology · 2019Article
- GEORG SCHMORL PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2018: combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Methodology to Produce Specimen-Specific Models of Vertebrae: Application to Different Species.Annals of biomedical engineering · 2017Article
- Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.Royal Society open science · 2017Article
- Modelling the failure precursor mechanism of lamellar fibrous tissues, example of the annulus fibrosus.Journal of the mechanical behavior of biomedical materials · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The inter-lamellar connectivity of the annulus fibrosus in the intervertebral disc has been shown to affect the prediction of the overall disc behaviour in computational models. Using a combined experimental and computational approach, the inter-lamellar mechanical behaviour of the disc annulus was investigated under conditions of radial loading. Twenty-seven specimens of anterior annulus fibrosus were dissected from 12 discs taken from four frozen ovine thoracolumbar spines. Specimens were grouped depending on their radial provenance within the annulus fibrosus. Standard tensile tests were performed. In addition, micro-tensile tests under microscopy were used to observe the displacement of the lamellae and inter-lamellar connections. Finite elements models matching the experimental protocols were developed with specimen-specific geometries and boundary conditions assuming a known lamellar behaviour. An optimisation process was used to derive the interface stiffness values for each group. The assumption of a linear cohesive interface was used to model the behaviour of the inter-lamellar connectivity. The interface stiffness values derived from the optimisation process were consistently higher than the corresponding lamellar values. The interface stiffness values of the outer annulus were from 43% to 75% higher than those of the inner annulus. Tangential stiffness values for the interface were from 6% to 39% higher than normal stiffness values within each group and similar to values reported by other investigators. These results reflect the intricate fibrous nature of the inter-lamellar connectivity and provide values for the representation of the inter-lamellar behaviour at a continuum level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.