ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2015
Risk factors for acute asthma in tropical America: a case-control study in the City of Esmeraldas, Ecuador.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The relationship of domestic pet ownership with the risk of childhood asthma: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Association between early bronchiolitis and the development of childhood asthma: a meta-analysis.BMJ open · 2021Pooled it
- Role of Toll-like Receptors Nine and Ten Polymorphisms in Childhood Bronchial Asthma Control and Their Relation to Cardiac Function.Diagnostics (Basel, Switzerland) · 2025Article
- Allergies, body mass, and hospitalization due to arbovirus infection: A prospective surveillance study in Machala, Ecuador.Epidemiology and infection · 2023Article
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Article
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Caregivers' and healthcare professionals' perspective of barriers and facilitators to health service access for asthmatic children: a qualitative study.BMJ open respiratory research · 2021Article
- Patterns of allergic sensitization and factors associated with emergence of sensitization in the rural tropics early in the life course: findings of an Ecuadorian birth cohort.Frontiers in allergy · 2021Article
- Impact of COVID-19 pandemic on asthma symptoms and management: A prospective analysis of asthmatic children in Ecuador.The World Allergy Organization journal · 2021Article
- Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city.PloS one · 2020Article
- Predictors of severe asthma attack re-attendance in Ecuadorian children: a cohort study.The European respiratory journal · 2019Article
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice.European clinical respiratory journal · 2017Review
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Risk factors for acute asthma in tropical America: a case-control study in the City of Esmeraldas, Ecuador.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
- What can we learn from measuring IgE to allergens and allergen components in tropical and subtropical settings in Brazil?Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundDespite the high asthma rates described in Latin America, asthma risk factors in poor urban settings are not well established. We investigated risk factors for acute asthma among Ecuadorian children.
methodsA matched case-control study was carried out in a public hospital serving a coastal city. Children with acute asthma were age- and sex-matched to non-asthmatics. A questionnaire was administered, and blood, as well as stool, and nasopharyngeal swabs were collected.
resultsSixty cases and 119 controls aged 5-15 were evaluated. High proportions of cases were atopic with population-attributable fractions for atopy of 68.5% for sIgE and 57.2% for SPT. Acute asthma risk increased with greater titers of mite IgE (3.51-50 kU/l vs. <0.70kU/l - OR 4.56, 95% CI 1.48-14.06, p = 0.008; >50kU/l vs. <0.70kU/l - OR 41.98, 95% CI: 8.97-196.39, p < 0.001). Asthma risk was significantly independently associated with bronchiolitis (adj. OR: 38.9, 95% CI 3.26-465), parental educational level (adj. OR 1.26, 95% CI: 1.08-1.46), and presence of sIgE (adj. OR: 36.7, 95% CI: 4.00-337), while a reduced risk was associated with current contact with pets (adj. OR: 0.07, 95% CI: 0.01-0.56). Rhinovirus infection was more frequent in cases (cases 35.6% vs. controls 7.8%, p = 0.002). None of the cases were on maintenance therapy with inhaled corticosteroids and most relied on emergency department for control.
conclusionsA high proportion of children presenting to a public hospital with acute asthma were allergic to mite, particularly at high IgE titer. Poor asthma control resulted in overuse of emergency care.
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